PMID: 6977009Feb 1, 1982Paper

Mechanisms of syngeneic tumor rejection. Susceptibility of host-selected progressor variants to various immunological effector cells

The Journal of Experimental Medicine
J L UrbanH Schreiber

Abstract

The ultraviolet radiation-induced fibrosarcoma 1591 generally is rejected by normal syngeneic mice and only rarely exhibits progressive growth. We isolated five of these rare progressor tumors from normal animals to determine the selective pressures that had been exerted upon the parental tumor by normal immunocompetent hosts. We found that the variant tumor cell lines could neither induce nor be killed by tumor-specific lymphocytes, suggesting that selection had been exerted against tumor cells expressing the tumor-specific antigen. In contrast, no selection against natural killer cell activity or against nonspecific T cell-mediated immunity seems to have occurred because progressor tumor cells were highly sensitive to these types of effector cells and in fact induced these effector cells more effectively than did the parental tumor. Nude mice were found to be as capable as normal mice in generating natural killer activity in response to a challenge with progressor tumor cells, but they were unable to mount a nonspecific T lymphocyte response. This may account for the fact that the progressor tumors grew at a significantly faster rate in nude animals than in normal mice. Thus, our study shows that in this tumor system nonspeci...Continue Reading

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Citations

Jan 1, 1982·Cancer Metastasis Reviews·V SchirrmacherL Beck
Jan 1, 1982·Cancer Metastasis Reviews·F R Miller
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May 3, 2013·Proceedings of the National Academy of Sciences of the United States of America·Rebecca Berlant LiuBana Jabri
Apr 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·R D WortzelH Schreiber
Aug 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·C PhilippsH Schreiber
Aug 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·M McMillanD M Rovner
Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J L UrbanH Schreiber
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·R M HudziakH M Shepard
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