PMID: 11595837Oct 12, 2001Paper

Mechanisms of tamoxifen-induced apoptosis

Apoptosis : an International Journal on Programmed Cell Death
S Mandlekar, A N Kong


Tamoxifen (TAM) has been used in the treatment of breast cancer for over a decade. The observed clinical efficacy of TAM has been attributed to both growth arrest and induction of apoptosis within the breast cancer cells. Although the primary mechanism of action of TAM is believed to be through the inhibition of estrogen receptor (ER), research over the years has indicated that additional, non-ER-mediated mechanisms exist. These include modulation of signaling proteins such as protein kinase C (PKC), calmodulin, transforming growth factor-beta (TGFbeta), and the protooncogene c-myc. Recent studies, including those from our laboratory, have implicated the role of caspases and mitogen-activated protein kinases (MAPK), including c-Jun N-terminal kinase (JNK) and p38 in TAM-induced apoptotic signaling. Oxidative stress, mitochondrial permeability transition (MPT), ceramide generation as well as changes in cell membrane fluidity may also play important roles in TAM-induced apoptosis. These various signaling pathways underlying TAM-induced apoptosis will be reviewed in this article.


Dec 24, 2015·Oxidative Medicine and Cellular Longevity·Tarek K MotawiSamia A Shouman
Mar 7, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Petri LehenkariH Kalervo Väänänen
Aug 7, 2003·Oncogene·Ramsey I CutressGraham Packham
Jul 13, 2006·Assay and Drug Development Technologies·Xin JiangXianqiang Li
Feb 1, 2007·Proceedings of the National Academy of Sciences of the United States of America·Hon-Wai KoonCharalabos Pothoulakis
Jul 12, 2007·Journal of Biochemical and Molecular Toxicology·Heena TabassumSheikh Raisuddin
Jul 25, 2007·Molecular and Cellular Biochemistry·Aliccia BolligJoshua D Liao
Dec 24, 2008·Genesis : the Journal of Genetics and Development·Hirohide TakebayashiKazuhiro Ikenaka
Apr 6, 2011·Laboratory Investigation; a Journal of Technical Methods and Pathology·Gu JingYabing Chen
Apr 26, 2012·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Leslie J DickmannYvonne S Lin
Oct 31, 2012·Apoptosis : an International Journal on Programmed Cell Death·Xu-Dong WuXiu-Hua Liu
Oct 15, 2013·Chemical Biology & Drug Design·Vivian I BonanoSilvia R B Uliana
Apr 12, 2013·Biological & Pharmaceutical Bulletin·Wen-zhi GuoTakao Yamori
Feb 1, 2009·Evolutionary Applications·John W PepperCarlo C Maley
Jun 17, 2016·Molecular & Cellular Oncology·Abel Sánchez-Aguilera, Simón Méndez-Ferrer
Mar 5, 2019·Biological & Pharmaceutical Bulletin·Takumi IwasawaYukitoshi Nagahara
Jan 22, 2004·Experimental Biology and Medicine·Ernest B IzevbigieAlice Walker
Mar 16, 2006·Apoptosis : an International Journal on Programmed Cell Death·S CagnolJ-C Chambard
Jun 7, 2006·Pharmacogenomics·Ji-Yeob ChoiChristine B Ambrosone
Nov 6, 2007·Breast Cancer Research : BCR·Alison J ButtElizabeth A Musgrove

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.


Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis