Abstract
Mitogenic growth factors stimulate cell growth by initiating a signaling cascade leading to the activation of the cyclin-dependent kinases (cdks), phosphorylation of pRb, and subsequent entry of the cell into the S phase. Transforming growth factor-beta (TGF-beta) is a potent antimitogen in a wide variety of cells and is postulated to inhibit cell cycle progression by blocking the late G1 activation of the cdks, thereby preventing pRb phosphorylation and S phase entry. The loss of TGF-beta sensitivity in many transformed cells coupled with recent data demonstrating a deregulation of cyclins, cdks, and cdk inhibitors in many types of cancer has attracted much attention to the molecular mechanism of TGF-beta-mediated growth arrest. Despite these recent advances, further research is required to elucidate how these effects of TGF-beta on the cyclins, cdks, and cdk inhibitors are linked to the TGF-beta receptor complex and the Smad proteins.
Citations
Feb 15, 2001·Microscopy Research and Technique·P WikströmA Bergh
Nov 15, 2001·Pharmacology & Therapeutics·J Yue, K M Mulder
Oct 3, 1999·Kidney International·S N WangR Hirschberg
May 5, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S DooleyA M Gressner
Aug 3, 1999·The Journal of Experimental Medicine·C MillerR H Schwartz
Jan 14, 1999·Genes & Development·T BrummelM B O'Connor
Sep 20, 2007·Journal of Cell Science·Chun-Lin ChenJung San Huang
Apr 14, 2015·Seminars in Cancer Biology·W G JiangD Santini
May 12, 2004·FEBS Letters·Shuan Shian HuangJung San Huang
Jan 29, 2009·Journal of Neuroimmunology·Qing-Fei KongHu-Lun Li
Aug 10, 2005·Transfusion·James D Gorham
Aug 10, 2005·Journal of Cellular Biochemistry·Shuan S Huang, Jung S Huang
May 12, 2006·Biology of the Cell·Kaijun DiXianghong Wang
May 1, 2012·Biochemical and Biophysical Research Communications·Shinji Kawai, Atsuo Amano
Feb 3, 2000·Experimental Eye Research·J K SunD A Carper
Mar 27, 2004·FEBS Letters·Wen-Fang TsengJung San Huang
Jan 19, 2017·Journal of Clinical Medicine·Qiuchen GuoPepper Schedin
Nov 5, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shuan Shian HuangJung San Huang
Apr 2, 1999·Oncogene·S DennlerJ M Gauthier
May 20, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·D L Harris, N C Joyce
Aug 30, 2005·Laboratory Investigation; a Journal of Technical Methods and Pathology·Ralf JesnowskiMatthias Löhr
Aug 7, 1999·The Journal of Biological Chemistry·T L BrownP H Howe
Feb 24, 2006·The Journal of Biological Chemistry·Chun-Lin ChenJung San Huang
Feb 29, 2016·Journal of Biomedical Science·C L ChenP H Yang
Jul 21, 2000·Scandinavian Journal of Urology and Nephrology·P WikströmJ E Damber
Dec 11, 2019·Cancers·Antje M RichterReinhard H Dammann
Jan 16, 2021·Microvascular Research·Lingzhi HuXin Cheng