Mechanisms of the Anti-Ischemic Effect of Angiotensin II AT( 1 ) Receptor Antagonists in the Brain.

Cellular and Molecular Neurobiology
Juan M SaavedraJin Zhou

Abstract

1. Circulating and locally formed Angiotensin II regulates the cerebral circulation through stimulation of AT(1) receptors located in cerebrovascular endothelial cells and in brain centers controlling cerebrovascular flow. 2. The cerebrovascular autoregulation is designed to maintain a constant blood flow to the brain, by vasodilatation when blood pressure decreases and vasoconstriction when blood pressure increases. 3. During hypertension, there is a shift in the cerebrovascular autoregulation to the right, in the direction of higher blood pressures, as a consequence of decreased cerebrovascular compliance resulting from vasoconstriction and pathological growth. In hypertension, when perfusion pressure decreases as a consequence of blockade of a cerebral artery, reduced cerebrovascular compliance results in more frequent and more severe strokes with a larger area of injured tissue. 4. There is a cerebrovascular angiotensinergic overdrive in genetically hypertensive rats, manifested as an increased expression of cerebrovascular AT(1) receptors and increased activity of the brain Angiotensin II system. Excess AT(1) receptor stimulation is a main factor in the cerebrovascular pathological growth and decreased compliance, the alte...Continue Reading

References

May 1, 1992·Endocrine Reviews·J M Saavedra
Mar 1, 1994·Proceedings of the Society for Experimental Biology and Medicine·R M McCarronJ M Hallenbeck
Dec 31, 1997·The Journal of Clinical Investigation·D G Harrison
Dec 10, 1999·Regulatory Peptides·J M Saavedra
Feb 9, 2000·American Journal of Physiology. Cell Physiology·J A BurasW R Reenstra
Apr 5, 2000·Journal of Neuropathology and Experimental Neurology·M StaykovaD Willenborg
Oct 29, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R ScaliaA M Lefer
Feb 28, 2002·Journal of Cardiovascular Pharmacology·Ana M BrionesMercedes Salaices
Feb 28, 2002·Trends in Immunology·Robert P A WallinHans-Gustaf Ljunggren
Apr 17, 2002·Medical Electron Microscopy : Official Journal of the Clinical Electron Microscopy Society of Japan·K SuzukiM Takatama
Dec 20, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Oliver RitterLudwig Neyses
Jan 11, 2003·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·B SchöningC Woiciechowsky
Mar 7, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Haruki YamakawaJuan M Saavedra
Jun 21, 2003·Stroke; a Journal of Cerebral Circulation·Joachim SchraderUNKNOWN Acute Candesartan Cilexetil Therapy in Stroke Survivors Study Group
Aug 28, 2003·Clinical and Experimental Hypertension : CHE·Francesco AmentaDaniele Tomassoni
Nov 19, 2003·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yasuaki DohiRyuzo Ueda
Dec 24, 2003·Hypertension·Wendy W BatenburgA H Jan Danser
Feb 21, 2004·Stroke; a Journal of Cerebral Circulation·Carlene M M LawesAnthony Rodgers
May 1, 2004·Circulation·Wendy W BatenburgA H Jan Danser
Dec 9, 2004·Current Opinion in Nephrology and Hypertension·Robert M Carey
Jan 18, 2005·Journal of Cardiovascular Pharmacology·Sandra Y FukadaAna M de Oliveira
Feb 25, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jin ZhouJuan M Saavedra
Aug 3, 2005·Cellular and Molecular Neurobiology·Juan M Saavedra

❮ Previous
Next ❯

Citations

Mar 5, 2009·Cellular and Molecular Neurobiology·Julius BenickyJuan M Saavedra
Sep 18, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Shuzhen ChenYanfang Chen
Mar 25, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Masaru IwaiMasatsugu Horiuchi
May 13, 2014·Current Hypertension Reports·Claudia A McCarthyRobert E Widdop
May 4, 2010·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Riya NagataKen Ikeda
Apr 15, 2010·Brain Research·Yukiko KasaharaTomohiro Matsuyama
Sep 23, 2008·Pharmacology & Therapeutics·Emma S JonesRobert E Widdop
Jul 1, 2008·Journal of the American Society of Hypertension : JASH·Björn Dahlöf
Jan 21, 2014·Neuropharmacology·Ji ChenYanfang Chen
Jul 9, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Lise Grimmeshave Bie-OlsenBirger Thorsteinsson
Feb 16, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Nicole A TerpolilliNikolaus Plesnila
May 23, 2014·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Gali UmschweifEsther Shohami
Jan 29, 2011·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Mohammadali M ShojaAaron A Cohen-Gadol
Nov 22, 2008·Stroke; a Journal of Cerebral Circulation·Shinji InabaMasatsugu Horiuchi
Sep 18, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Saema AnsarLars Edvinsson
May 1, 2019·Journal of Neurotrauma·Zachary C JanatpourAviva J Symes
Nov 10, 2017·Neurology·Angela L JeffersonManus J Donahue
Dec 24, 2010·British Journal of Pharmacology·Masatsugu Horiuchi, Masaki Mogi
Sep 10, 2020·International Journal of Molecular Sciences·Stefan WandererJürgen Konczalla
Feb 2, 2011·Shock·Diamantino Ribeiro SalgadoJean-Louis Vincent
May 13, 2009·Current Opinion in Neurology·Timothy J Kleinig, Robert Vink
Jan 29, 2022·JAMA Network Open·Zachary A MarcumUNKNOWN Systolic Blood Pressure Intervention Trial (SPRINT) Research Group

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.

Ataxia telangiectasia (MDS)

Ataxia telangiectasia is a rare neurodegenerative diseases caused by defects in the ATM gene, which is involved in DNA damage recognition and repair pathways. Here is the latest research on this autosomal recessive disease.

Related Papers

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Thomas WaltherGünter Mies
Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension
Rainer Schulz, Gerd Heusch
© 2022 Meta ULC. All rights reserved