Mechanisms of the respiratory activity of leptin at the level of the solitary tract nucleus.

Neuroscience and Behavioral Physiology
E M InyushkinaA N Inyushkin

Abstract

Acute experiments on anesthetized laboratory rats were performed to study the effects microinjections of 10(-4) M leptin into the solitary tract nucleus on the extent of the Hering-Breuer inflation reflex in ventilatory reactions to hypercapnia. Local administration of leptin into this area led to inhibition of the Hering-Breuer reflex. The extent of ventilatory responses to hypercapnia, conversely, increased, which may provide evidence that leptin has a modulatory influence on central chemoreceptors. These physiological mechanisms of action probably play a leading role in mediating the stimulatory respiratory effects of leptin at the level of the solitary tract nucleus.

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Citations

Oct 13, 2018·American Journal of Respiratory and Critical Care Medicine·Slava BergerVsevolod Y Polotsky
Jul 1, 2020·American Journal of Respiratory Cell and Molecular Biology·Carla FreireVsevolod Y Polotsky
Mar 7, 2012·Sleep & Breathing = Schlaf & Atmung·Marco CarotenutoMaurizio Elia
Oct 23, 2013·European Journal of Pediatrics·Giulia GenoniGianni Bona
Feb 22, 2014·Journal of Applied Physiology·Steven D ShapiroAlan R Schwartz
Jun 23, 2015·The Journal of Physiology·M BassiE Colombari
Feb 22, 2012·Journal of Applied Physiology·Mikhael PolotskyAlan R Schwartz
Aug 24, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·John Ciriello, Jason M Moreau
Jul 11, 2014·Frontiers in Physiology·Daniel B ZoccalEduardo Colombari
Oct 27, 2016·Anesthesia and Analgesia·Nicholas M DalesioAlan R Schwartz
Aug 11, 2017·Annals of the American Thoracic Society·Ikuyo Imayama, Bharati Prasad
May 17, 2018·Sleep·Thomaz Fleury CuradoVsevolod Y Polotsky
Jul 24, 2020·International Journal of Molecular Sciences·Lenise J Kim, Vsevolod Y Polotsky
Nov 19, 2011·Journal of Applied Physiology·Chien-Hung ChinHartmut Schneider
Nov 12, 2020·Cell Reports·Jeehaeh DoMarco Martina
Jul 3, 2021·International Journal of Molecular Sciences·Mateus R AmorimVsevolod Y Polotsky

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