Mechanisms of thyroid hormone receptor action during development: lessons from amphibian studies

Biochimica Et Biophysica Acta
Alexis GrimaldiLaurent M Sachs

Abstract

Thyroid hormone (TH) receptor (TR) plays critical roles in vertebrate development. However, the in vivo mechanism of TR action remains poorly explored. Frog metamorphosis is controlled by TH and mimics the postembryonic period in mammals when high levels of TH are also required. We review here some of the findings on the developmental functions of TH and TR and the associated mechanisms obtained from this model system. A dual function model for TR in Anuran development was proposed over a decade ago. That is, unliganded TR recruits corepressors to TH response genes in premetamorphic tadpoles to repress these genes and prevent premature metamorphic changes. Subsequently, when TH becomes available, liganded TR recruits coactivators to activate these same genes, leading to metamorphic changes. Over the years, molecular and genetic approaches have provided strong support for this model. Specifically, it has been shown that unliganded TR recruits histone deacetylase containing corepressor complexes during larval stages to control metamorphic timing, while liganded TR recruits multiple histone modifying and chromatin remodeling coactivator complexes during metamorphosis. These complexes can alter chromatin structure via nucleosome po...Continue Reading

References

Mar 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·B BlumbergE M De Robertis
Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·Z Wang, D D Brown
Nov 25, 1989·Nucleic Acids Research·A R BrooksR W Old
Dec 18, 1986·Nature·C WeinbergerR M Evans
Apr 1, 1993·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·J R Tata
Mar 5, 1996·Proceedings of the National Academy of Sciences of the United States of America·D D BrownA Pinder
May 1, 1997·Nature·A P Wolffe
Jan 5, 2000·Genes & Development·V PerissiM G Rosenfeld
Jan 5, 2000·Genes & Development·L NagyJ W Schwabe
Jan 19, 2000·Nature·B D Strahl, C D Allis
Nov 15, 2000·Proceedings of the National Academy of Sciences of the United States of America·L M Sachs, Y B Shi
Mar 20, 2001·The Journal of Biological Chemistry·P L JonesY B Shi
Aug 23, 2001·Proceedings of the National Academy of Sciences of the United States of America·A M SchreiberD D Brown
Jul 16, 2003·Molecular and Cellular Biology·Takahiro Ishizuka, Mitchell A Lazar
Aug 30, 2003·EMBO Reports·Emmanuelle HavisBarbara A Demeneix
Aug 3, 2004·Journal of Cell Science·Anton Eberharter, Peter B Becker
Nov 2, 2005·Nature Reviews. Molecular Cell Biology·Cyrus Martin, Yi Zhang

❮ Previous
Next ❯

Citations

Feb 6, 2014·BMC Developmental Biology·Taka-Aki IchuCaren C Helbing
Mar 17, 2015·Journal of Neurochemistry·Richa KapoorVidita A Vaidya
May 29, 2016·BMC Genomics·Ricardo N AlvesDeborah M Power
Mar 5, 2013·Toxicology in Vitro : an International Journal Published in Association with BIBRA·AlberTinka J MurkArno C Gutleb
Aug 25, 2016·Reviews in Endocrine & Metabolic Disorders·Guihong SunYun-Bo Shi
Jan 23, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Syunsuke OtsukaKiyoshi Yamauchi
Jan 22, 2017·Genesis : the Journal of Genetics and Development·Laurent M Sachs, Daniel R Buchholz
May 16, 2018·Endocrinology·Brenda J MengelingJ David Furlow
Nov 1, 2013·Journal of Molecular Endocrinology·Changhua ShiDavid W Wood
May 10, 2019·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Natacha RouxVincent Laudet
Apr 26, 2020·International Journal of Molecular Sciences·Henrik HolbechLisa Baumann
May 31, 2019·Frontiers in Endocrinology·Laurent M Sachs, Daniel R Buchholz
Jan 2, 2021·Molecular and Cellular Endocrinology·Sakae KikuyamaReiko Okada
Dec 4, 2019·General and Comparative Endocrinology·Keisuke NakajimaYun Bo Shi
Feb 3, 2021·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Alicia TribondeauNicolas Buisine
Feb 10, 2021·Endocrinology·Yun-Bo Shi
Feb 26, 2021·Journal of Thermal Biology·Xiaoyan ChenHongyuan Wang
Feb 24, 2021·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Yuki TairaYuji Kageyama
Apr 1, 2021·Archives of Environmental Contamination and Toxicology·Ethan A Abbott, Caren C Helbing

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.