Mechanisms of tissue injury in renal artery stenosis: ischemia and beyond.

Progress in Cardiovascular Diseases
Lilach LermanJoseph P Grande

Abstract

Renal injury distal to an atherosclerotic renovascular obstruction reflects multiple intrinsic factors producing parenchymal tissue injury. Atherosclerotic disease pathways superimposed on renal arterial obstruction may aggravate damage to the kidney and other target organs, and some of the factors activated by renal artery stenosis may in turn accelerate the progression of atherosclerosis. This cross-talk is mediated through amplified activation of renin-angiotensin system, oxidative stress, inflammation, and fibrosis-pathways notoriously involved in renal disease progression. Oxidation of lipids also accelerates the development of fibrosis in the stenotic kidney by amplifying profibrotic mechanisms and disrupting tissue remodeling. The extent to which actual ischemia modulates injury in the stenotic kidney has been controversial, partly because the decrease in renal oxygen consumption usually parallels a decrease in renal blood flow, and because renal vein oxygen pressure in the affected kidney is not decreased. However, recent data using novel methodologies demonstrate that intra-renal oxygenation is heterogeneously affected in different regions of the kidney. Activation of such local injury within the kidney may lead to ren...Continue Reading

References

Mar 1, 1992·Clinical Physiology·K NielsenJ H Henriksen
Mar 1, 1990·Kidney International·B L KasiskeW F Keane
Jan 1, 1987·Clinical and Experimental Hypertension. Part A, Theory and Practice·I MiyamoriR Takeda
Jan 1, 1988·American Journal of Nephrology·W F KeaneM P O'Donnell
May 1, 1988·Kidney International·J R Diamond, M J Karnovsky
Oct 1, 1984·Kidney International·M BrezisF H Epstein
Jun 1, 1993·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·H Haller
Feb 1, 1997·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·B A Greco, J A Breyer
Jan 1, 1996·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·A Meyrier
Jul 1, 1997·Current Opinion in Nephrology and Hypertension·T E Hunley, V Kon
Jul 2, 1998·Kidney International·A MeyrierP Simon
Jul 15, 1999·Journal of the American Society of Nephrology : JASN·L O LermanJ C Romero
Sep 16, 1999·The Journal of Clinical Investigation·M A DaemenW A Buurman
May 16, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·M SureshP A Kalra
Sep 21, 2000·Kidney International. Supplement·H MakinoN Kashihara
Sep 29, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·H DejaniF O Finkelstein
Feb 13, 2001·Annual Review of Medicine·S C Textor, C S Wilcox
Feb 13, 2001·Kidney International·C Guijarro, J Egido
Mar 3, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·D H KangR J Johnson
Mar 29, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·J R WrightP A Kalra
Aug 24, 2001·Journal of the American Society of Nephrology : JASN·John M StulakLilach O Lerman
Oct 11, 2001·American Journal of Physiology. Renal Physiology·D P BasileJ L Osborn
Jan 17, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Christine G Schnackenberg
Feb 19, 2002·Kidney International·Michael D BentleyLilach O Lerman
Mar 30, 2002·American Heart Journal·Aseem VashistImad A Alhaddad
May 3, 2002·Journal of the American College of Cardiology·Jawahar L Mehta, Dayuan Li
May 9, 2002·American Journal of Physiology. Renal Physiology·Sergey V BrodskyMichael S Goligorsky
May 25, 2002·The British Journal of Surgery·W R PillayUNKNOWN Joint Vascular Research Group, UK
Aug 28, 2002·Circulation·Alejandro R ChadeLilach O Lerman
Sep 10, 2002·Journal of Vascular Surgery·Kimberley J HansenRichard H Dean
Oct 3, 2002·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Takashi UzuGenjiro Kimura
Nov 22, 2002·Journal of the American Society of Nephrology : JASN·Duk-Hee KangRichard J Johnson
Dec 25, 2002·European Journal of Pharmacology·Ozge Uzun, A Tuncay Demiryürek
Feb 7, 2003·Journal of the American College of Cardiology·Guruprasad ManjunathMark J Sarnak
May 17, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Alejandro R ChadeLilach O Lerman
Aug 20, 2003·Hypertension·Alejandro R ChadeLilach O Lerman
Apr 1, 1961·Acta Physiologica Scandinavica·N A LASSENJ H THAYSEN
Jan 15, 2004·American Journal of Physiology. Renal Physiology·Alejandro R ChadeLilach O Lerman

❮ Previous
Next ❯

Citations

Sep 6, 2012·Pflügers Archiv : European journal of physiology·Shetal H Padia, Robert M Carey
Aug 13, 2011·Current Hypertension Reports·Monika L GloviczkiStephen C Textor
Jun 15, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Se Won OhSuhnggwon Kim
Jul 13, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Niina KoivuviitaKaj Metsärinne
Dec 16, 2010·Current Opinion in Nephrology and Hypertension·Stephen C Textor
Mar 4, 2011·American Journal of Physiology. Renal Physiology·Alfonso EirinLilach O Lerman
Oct 29, 2013·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Behzad EbrahimiLilach O Lerman
Oct 8, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Alfonso EirinLilach O Lerman
Dec 19, 2013·Journal of Postgraduate Medicine·A S GulatiS Srinivas
Jul 9, 2013·Clinical and Experimental Nephrology·Naoki ShiraishiKimio Tomita
Mar 7, 2014·European Heart Journal·Augusto GallinoUNKNOWN European Society of Cardiology Working Group on Peripheral Circulation
Jul 3, 2013·Physiology·Alfonso Eirin, Lilach O Lerman
Jan 19, 2016·Journal of the American Society of Hypertension : JASH·James RitchiePhilip A Kalra
Nov 12, 2013·Advances in Chronic Kidney Disease·Junjie ChenSamuel A Wickline
Apr 26, 2013·Kidney International·Xin ZhangLilach O Lerman
Mar 6, 2016·Journal of the American Society of Hypertension : JASH·Alan Alper SagMehmet Kanbay
Nov 18, 2009·Progress in Cardiovascular Diseases·Vincent J Canzanello, Vesna D Garovic
Jan 21, 2016·Clinical Journal of the American Society of Nephrology : CJASN·Sandra M S HerrmannStephen C Textor
Aug 21, 2014·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Sahil A ParikhMichael R Jaff
Aug 5, 2015·Current Cardiology Reports·Sandeep M PatelSahil A Parikh
Apr 25, 2015·Advances in Chronic Kidney Disease·Soon Hyo Kwon, Lilach O Lerman
Feb 5, 2015·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Maristela Böhlke, Franklin Correa Barcellos
Nov 4, 2016·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Delia Lidia ŞalaruPeter R Mertens
Jul 12, 2016·Clinical and Experimental Hypertension : CHE·Zarife Nigâr Özdemir KumralBerrak Ç Yeğen
Nov 4, 2016·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ahmed SaadStephen C Textor
Sep 30, 2016·Clinical Kidney Journal·Reem Daloul, Aubrey R Morrison
Apr 25, 2015·Therapeutic Advances in Cardiovascular Disease·Luis I Juncos, Stephen Textor
Sep 13, 2011·Vascular Medicine·Haifeng YuChristopher J Cooper
Oct 7, 2017·American Journal of Hypertension·Sandra M Herrmann, Stephen C Textor
Aug 26, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Rafael S LindosoMarcelo Einicker-Lamas
Jan 24, 2018·Clinical and Experimental Hypertension : CHE·Douglas Vq NunesDayane T Ognibene
Jul 4, 2018·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Daan J L van TwistAbraham A Kroon
Mar 3, 2010·Hypertension·Robert M Carey
Feb 23, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Alfonso EirinLilach O Lerman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Carotid Artery Diseases

Carotid artery disease is a group of pathological conditions of the carotid artery. Discover the latest research on carotid artery disease here.

Related Papers

American Journal of Physiology. Renal Physiology
Victor H Urbieta-CaceresLilach Lerman
Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Mira T KeddisJoseph P Grande
© 2022 Meta ULC. All rights reserved