PMID: 9421878Jan 1, 1997Paper

Mechanisms of transcriptional regulation of cellular genes by SV40 large T- and small T-antigens

Virus Genes
U MoensO P Rekvig

Abstract

During the past decade a number of virus-encoded transcriptional trans-activators that regulate the expression of viral genes have been reported. These trans-activators may also affect the expression or activity of several cellular genes or gene products to create an optimal cellular environment that favors viral replication. Among the better-studied viral trans-activating proteins are the Simian virus 40 large T- and small t-antigens. During the last few years, mechanisms by which these two viral proteins influence cellular gene expression start to emerge. They are grouped provisionally and reflect the methods used to determine the effects of large T-antigen. Large T-antigen may influence cellular gene expression by: i. altering mRNA levels of cellular transcription factors; ii. interacting with and regulating the DNA-binding or transcriptional activity of specific transcription factors; iii. functionally substitution of eukaryotic transcription factors; iv. direct binding to DNA; or v. regulating components of signaling transduction pathways. Small t-ag seems to exert its effect mainly through inhibiting a cellular phosphatase, protein phosphatase 2A, thereby modulating components of signal transduction pathways and preventin...Continue Reading

Citations

Sep 6, 2000·European Journal of Biochemistry·K Van CraenenbroeckG Haegeman
Dec 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Signy BendiksenOle Petter Rekvig
Nov 20, 1998·Molecular and Cellular Biology·K P MullaneB Schaffhausen
Mar 16, 2011·The Journal of Biological Chemistry·Yuki MorizaneDemetrios G Vavvas
Aug 25, 2018·Oncotarget·Kashif RasheedUgo Moens
Jun 21, 2001·Biochemical and Biophysical Research Communications·K R LaderouteR S Johnson
May 16, 2001·Biochemical and Biophysical Research Communications·S MacKenzieW Lockette
Jul 25, 2006·Journal of Molecular Biology·Dimitrios NoutsopoulosTheodore Tzavaras
Dec 26, 2003·The American Journal of Pathology·Katerina PolitiArgiris Efstratiadis

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