Mechanisms of transcriptional synergism of eukaryotic genes. The interferon-beta paradigm

Hypertension
D Thanos

Abstract

The virus-inducible enhancer of the human interferon-beta gene has served as an excellent example for the mechanisms controlling the activation and repression of transcription. This enhancer is activated by three different transcription factors that, with the help of the high mobility group protein HMG I(Y), assemble in a unique nucleoprotein complex that interacts as a unit with the basal transcriptional machinery. The assembly of unique enhancer complexes from similar sets of transcription factors may provide the specificity required for regulation of complex patterns of gene expression in higher eukaryotes.

References

Mar 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·W Du, T Maniatis
Mar 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·S Goodbourn, T Maniatis
Feb 24, 1995·Cell·D Thanos, T Maniatis
Jan 1, 1993·Cold Spring Harbor Symposia on Quantitative Biology·D ThanosT Maniatis
Sep 12, 1957·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·A ISAACS, J LINDENMANN

❮ Previous
Next ❯

Citations

Dec 22, 1999·The Journal of Experimental Medicine·S GuptaA B Pernis
Nov 30, 2000·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·J L HarcourtM K Offermann
Feb 16, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Alessandra B Pernis
Jan 7, 2011·Journal of Virology·Suresh H BasagoudanavarSiddharth Balachandran
Jan 3, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·D HamamdzicL London
Oct 11, 2002·The Journal of Biological Chemistry·Chuan-Min HuAlessandra B Pernis

❮ Previous
Next ❯

Related Concepts

Related Feeds

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.