PMID: 11345193May 10, 2001Paper

Mechanisms of transformation by the BCR/ABL oncogene

International Journal of Hematology
M Sattler, J D Griffin

Abstract

The Philadelphia chromosome generates a chimeric oncogene in which the BCR and c-ABL genes are fused. The product of this oncogene, BCR/ABL, has elevated ABL tyrosine kinase activity, relocates to the cytoskeleton, and phosphorylates multiple cellular substrates. BCR/ABL transforms hematopoietic cells and exerts a wide variety of biological effects, including reduction in growth factor dependence, enhanced viability, and altered adhesion of chronic myelocytic leukemia (CML) cells. Elevated tyrosine kinase activity of BCR/ABL is critical for activating downstream signal transduction and for all aspects of transformation. This review will describe mechanisms of transformation by the BCR/ABL oncogene and opportunities for clinical intervention with specific signal transduction inhibitors such as STI-571 in CML.

References

Jul 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·A M PendergastO N Witte
Feb 1, 1991·Molecular and Cellular Biology·L VarticovskiL C Cantley
May 6, 1991·Biochimica Et Biophysica Acta·A R Cross, O T Jones
Jan 1, 1991·Annals of the New York Academy of Sciences·M Higgins
Mar 1, 1988·The Journal of Experimental Medicine·S P Staal, J W Hartley
Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·S P Staal
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·G Q Daley, D Baltimore
Oct 24, 1995·Proceedings of the National Academy of Sciences of the United States of America·T H ChuangG M Bokoch
Nov 21, 1995·Proceedings of the National Academy of Sciences of the United States of America·M L GishizkyA M Pendergast
Dec 8, 1995·The Journal of Biological Chemistry·R SalgiaL B Chen
Mar 10, 1995·The Journal of Biological Chemistry·R SalgiaT Ernst
Sep 15, 1995·The Journal of Biological Chemistry·R de JongJ Groffen
Apr 14, 1995·Science·E A Clark, J S Brugge
Apr 1, 1995·Free Radical Biology & Medicine·R H Burdon
May 1, 1995·British Journal of Haematology·J W JanssenL M Wiedemann
Feb 1, 1995·Journal of Leukocyte Biology·C Rosales, R L Juliano
Mar 10, 1995·Cell·J W VonckenJ Groffen
Aug 1, 1994·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·R Kapeller, L C Cantley

❮ Previous
Next ❯

Citations

Feb 15, 2002·International Journal of Hematology·Hiroki YamaguchiKazuo Dan
Dec 5, 2002·International Journal of Hematology·Yuka HiroseTomoki Naoe
Sep 5, 2003·International Journal of Hematology·Naoaki IchikawaHiroshi Saito
Feb 21, 2008·Cancer Metastasis Reviews·Gordon ChanBenjamin G Neel
Oct 22, 2013·International Journal of Hematology·Jonathan R HeyenBart Jessen
Aug 15, 2002·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Thomas M MaynardAnthony-Samuel LaMantia
Apr 12, 2003·Seminars in Hematology·Jerry L Spivak
Nov 2, 2002·The EMBO Journal·Agata KlejmanTomasz Skorski
Oct 5, 2013·Blood Cells, Molecules & Diseases·Cristian FerriIrene Larripa
Jan 17, 2016·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Ellen PlasschaertJean Steyaert
Aug 13, 2015·Nucleic Acids Research·Sarah Killcoyne, Antonio Del Sol
Nov 6, 2007·Biochimica Et Biophysica Acta·Zainab JaganiRoya Khosravi-Far
May 12, 2007·Molecular Microbiology·Yves TourretteJacky de Montigny
Jan 5, 2008·European Journal of Clinical Investigation·C SillaberP Valent
Mar 5, 2013·European Eating Disorders Review : the Journal of the Eating Disorders Association·Anja HilbertPetra Warschburger
Jan 16, 2014·Journal of Intellectual Disability Research : JIDR·L HaysomC Gaskin
Aug 18, 2004·Trends in Molecular Medicine·Kohei KometaniNagahiro Minato
Jun 19, 2010·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Timothy L Goth-OwensJoel T Nigg
Aug 8, 2008·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Michael E BehenHarry T Chugani
May 7, 2010·Journal of Learning Disabilities·Carsten Elbro
Feb 12, 2010·Journal of Pediatric Oncology Nursing : Official Journal of the Association of Pediatric Oncology Nurses·Kristina K HardyMelanie J Bonner
Jun 19, 2008·Journal of Pediatric Oncology Nursing : Official Journal of the Association of Pediatric Oncology Nurses·Margaret Gross-KingMarisa Couluris
May 1, 2008·Learning Disabilities Research & Practice : a Publication of the Division for Learning Disabilities, Council for Exceptional Children·Margaret Becker Patterson, Daryl Mellard
Jun 9, 2005·Journal of Learning Disabilities·Libbe KooistraBonnie J Kaplan
Mar 17, 2009·European Child & Adolescent Psychiatry·Marieke E AltinkJan K Buitelaar
Feb 11, 2009·Journal of the International Neuropsychological Society : JINS·Donald J MabbottAdrienne Witol
Mar 14, 2007·Journal of Abnormal Child Psychology·Amori Yee MikamiDana Hangai
Feb 3, 2009·Journal of Abnormal Child Psychology·Cynthia L Huang-PollockKeith McBurnett
Feb 24, 2009·Journal of Autism and Developmental Disorders·Adrienne PerryNancy L Freeman
Aug 21, 2008·Journal of Abnormal Child Psychology·Imola MartonRosemary Tannock
Aug 3, 2017·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Aleksandra MineykoAdam Kirton

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.