Mechanisms of Tumor Growth Inhibition by Depletion of γ-Glutamylcyclotransferase (GGCT): A Novel Molecular Target for Anticancer Therapy

International Journal of Molecular Sciences
Susumu KageyamaSusumu Nakata

Abstract

γ-Glutamylcyclotransferase (GGCT), which is one of the major enzymes involved in glutathione metabolism, is upregulated in a wide range of cancers-glioma, breast, lung, esophageal, gastric, colorectal, urinary bladder, prostate, cervical, ovarian cancers and osteosarcoma-and promotes cancer progression; its depletion leads to the suppression of proliferation, invasion, and migration of cancer cells. It has been demonstrated that the suppression or inhibition of GGCT has an antitumor effect in cancer-bearing xenograft mice. Based on these observations, GGCT is now recognized as a promising therapeutic target in various cancers. This review summarizes recent advances on the mechanisms of the antitumor activity of GGCT inhibition.

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Citations

Oct 20, 2020·Frontiers of Medicine·Deyu ZhangQinong Ye
Feb 19, 2021·Biochimica Et Biophysica Acta. Reviews on Cancer·Chit TamChi Chiu Wang
Mar 7, 2021·Biochemical and Biophysical Research Communications·Hiromi IiSusumu Nakata

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Methods Mentioned

BETA
DNA array
electrophoresis
transfection
xenograft
two-hybrid
immunoprecipitation
immunoprecipitation assay

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