Mechanisms of uterine estrogen signaling during early pregnancy in mice: an update

Journal of Molecular Endocrinology
I RobertshawS K Das

Abstract

Adherence of an embryo to the uterus represents the most critical step of the reproductive process. Implantation is a synchronized event between the blastocyst and the uterine luminal epithelium, leading to structural and functional changes for further embryonic growth and development. The milieu comprising the complex process of implantation is mediated by estrogen through diverse but interdependent signaling pathways. Mouse models have demonstrated the relevance of the expression of estrogen-modulated paracrine factors to uterine receptivity and implantation window. More importantly, some factors seem to serve as molecular links between different estrogen pathways, promoting cell growth, acting as molecular chaperones, or amplifying estrogenic effects. Abnormal expression of these factors can lead to implantation failure and infertility. This review provides an overview of several well-characterized signaling pathways that elucidates the molecular cross talk involved in the uterus during early pregnancy.

References

Jan 1, 1973·Vitamins and Hormones·A Psychoyos
Jun 1, 1973·The Journal of Endocrinology·L MartinC A Finn
Oct 1, 1973·The Journal of Endocrinology·R M Das, L Martin
May 1, 1969·The American Journal of Anatomy·A C Enders, S Schlafke
Dec 1, 1966·Journal of Reproduction and Fertility·K Yoshinaga, C E Adams
Jan 1, 1994·Annual Review of Biochemistry·M J Tsai, B W O'Malley
Nov 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·B C PariaS K Dey
Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·D B LubahnO Smithies
Dec 1, 1995·Molecular Reproduction and Development·Z M YangM J Harper
Jan 1, 1997·Annual Review of Immunology·T Taga, T Kishimoto
Jun 10, 1997·Proceedings of the National Academy of Sciences of the United States of America·P S CookeG R Cunha
Dec 16, 1997·Proceedings of the National Academy of Sciences of the United States of America·S K DasD B Lubahn
Jun 12, 1998·Biology of Reproduction·M M DeSouzaD D Carson
Aug 26, 1998·The Biochemical Journal·P C HeinrichL Graeve
Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·J H KregeO Smithies
Mar 23, 2000·Cancer Metastasis Reviews·M J Smalley, T C Dale
Feb 13, 2001·The Journal of Steroid Biochemistry and Molecular Biology·P J KushnerP Webb
Feb 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·C PendariesJ F Arnal
May 30, 2002·The Journal of Biological Chemistry·Hiromichi MatsumotoSudhansu K Dey
Sep 28, 2002·Molecular Endocrinology·Norio TakamotoFrancesco J DeMayo
Oct 9, 2002·The Journal of Biological Chemistry·Shao-Qing KuangJianming Xu
Feb 26, 2003·Proceedings of the National Academy of Sciences of the United States of America·Wen-ge MaSudhansu K Dey
Jun 7, 2003·Journal of Molecular Endocrinology·H WatanabeT Iguchi
Sep 11, 2004·Molecular Endocrinology·Xiaonan HouSanjoy K Das
Nov 25, 2004·Endocrine Reviews·Muktar A Mahajan, Herbert H Samuels
Mar 23, 2005·Archives of Histology and Cytology·Gerald R CunhaTakeshi Kurita
Apr 1, 2006·Molecular Endocrinology·Sanhita RaySanjoy K Das
Sep 5, 2006·Nature Genetics·Kevin LeeFrancesco J DeMayo
Sep 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·Haiyan PanJeffrey W Pollard

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Citations

Dec 28, 2017·Nature Reviews. Genetics·Vineet K DhimanKevin P White
Feb 13, 2020·Journal of Biochemical and Molecular Toxicology·Na TianDongmei Tan
Dec 6, 2018·Nature Communications·Carl van der LindenStephen W Santoro
Apr 5, 2020·Genes·Anna Idelevich, Felipe Vilella
Dec 1, 2020·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Fatemeh AzhariTuba Gunel
May 1, 2018·Trends in Endocrinology and Metabolism : TEM·San-Pin WuFrancesco J DeMayo
May 18, 2021·Frontiers in Cell and Developmental Biology·Babban JeeSubhradip Karmakar
Jul 27, 2021·Frontiers in Endocrinology·María Mercedes MilesiJorgelina Varayoud
Jul 9, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Virginia LorenzMaría M Milesi

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