Mechanisms of Vascular Aging, A Geroscience Perspective: JACC Focus Seminar.

Journal of the American College of Cardiology
Zoltan UngvariAnna Csiszar

Abstract

Age-related pathological alterations of the vasculature have a critical role in morbidity and mortality of older adults. In epidemiological studies, age is the single most important cardiovascular risk factor that dwarfs the impact of traditional risk factors. To develop novel therapeutic interventions for prevention of age-related vascular pathologies, it is crucial to understand the cellular and molecular mechanisms of vascular aging. In this review, shared molecular mechanisms of aging are considered in terms of their contribution to the pathogenesis of macrovascular and microvascular diseases associated with old age. The role of cellular senescence in development of vascular aging phenotypes is highlighted, and potential interventions to prevent senescence and to eliminate senescent cells for prevention of vascular pathologies are presented. The evidence supporting a role for interorgan communication and circulating progeronic and antigeronic factors in vascular aging is discussed.

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Citations

Sep 29, 2020·Hypertension·Mieczysław Litwin, Janusz Feber
May 31, 2020·Mechanisms of Ageing and Development·Maurizio ForteSperanza Rubattu
Nov 19, 2020·Cardiovascular Research·Véronique RegnaultPatrick Lacolley
Feb 20, 2021·Journal of the American College of Cardiology·Valentin Fuster
Apr 17, 2021·Reviews in Endocrine & Metabolic Disorders·Seda Hanife OguzBulent Okan Yildiz
Jul 10, 2021·Oxidative Medicine and Cellular Longevity·Zhen YangCuntai Zhang
May 22, 2021·The Journal of Clinical Endocrinology and Metabolism·Assaf BuchNaftali Stern
Jul 11, 2020·Journal of the American College of Cardiology·Rachel E ClimieDimitrios Terentes-Printzios
Aug 19, 2021·The Journal of Clinical Endocrinology and Metabolism·Assaf BuchNaftali Stern
Oct 1, 2021·Frontiers in Cardiovascular Medicine·Yongkang SuPing Zhu
Nov 12, 2021·GeroScience·Andrea Ágnes MolnárBéla Merkely

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