Mechanisms of vertebrate embryo segmentation: Common themes in trunk and limb development

Seminars in Cell & Developmental Biology
Caroline J SheebaIsabel Palmeirim

Abstract

Various ultradian rhythms ensure proper temporal regulations during embryo development. The embryo molecular clock, which was first identified in the presomitic mesoderm (PSM) underlying periodic somite formation, is one among them. Somites are the earliest manifestation of the segmented vertebrate body and they are formed with strict temporal precision. The tetrapod limb is also a segmented structure and the formation of limb bone elements have also been associated with a molecular clock, operating in the distal limb mesenchyme. In both the PSM and the distal limb mesenchyme, the molecular clock (MC) is influenced by FGF, SHH and RA, which are also the key regulators of the development of these tissues. While somitogenesis has been continuously scrutinized to understand the mechanisms of the MC, the limb bud has served as an outstanding paradigm to study how a cohort of undifferentiated cells is organized into functional 3D structures. The fact that both the trunk and limb development are shaped by the MC and by common signaling molecules has prompted the exciting possibility of establishing parallelisms between somitogenesis and limb development. Systematically correlating various parameters during trunk and limb development ...Continue Reading

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Citations

Feb 21, 2016·Seminars in Cell & Developmental Biology·Caroline J Sheeba
Aug 25, 2016·Seminars in Cell & Developmental Biology·Diane Catherine Wang, Xiangdong Wang
Feb 27, 2017·Arthropod Structure & Development·Alessandro Minelli
May 8, 2018·Journal of Morphology·George Lawrence PowellJennifer Sutey
Apr 30, 2017·Molecular Systems Biology·Alba JiménezJames Sharpe
Nov 9, 2019·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Emmanuelle Grall, Patrick Tschopp
Jan 31, 2020·Animal Genetics·J E AlderseyC D K Bottema
Oct 8, 2020·Development·Michel Bagnat, Ryan S Gray
Apr 7, 2021·Journal of Medical Genetics·Ichrak DrissiGeoff Woods

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