Mechanisms of xenobiotic receptor activation: Direct vs. indirect

Biochimica Et Biophysica Acta
Bryan Mackowiak, Hongbing Wang

Abstract

The so-called xenobiotic receptors (XRs) have functionally evolved into cellular sensors for both endogenous and exogenous stimuli by regulating the transcription of genes encoding drug-metabolizing enzymes and transporters, as well as those involving energy homeostasis, cell proliferation, and/or immune responses. Unlike prototypical steroid hormone receptors, XRs are activated through both direct ligand-binding and ligand-independent (indirect) mechanisms by a plethora of structurally unrelated chemicals. This review covers research literature that discusses direct vs. indirect activation of XRs. A particular focus is centered on the signaling control of the constitutive androstane receptor (CAR), the pregnane X receptor (PXR), and the aryl hydrocarbon receptor (AhR). We expect that this review will shed light on both the common and distinct mechanisms associated with activation of these three XRs. This article is part of a Special Issue entitled: Xenobiotic nuclear receptors: New Tricks for An Old Dog, edited by Dr. Wen Xie.

Citations

Sep 1, 2019·International Journal of Molecular Sciences·Deborah MinzaghiSandrine Dubrac
Mar 24, 2020·British Journal of Pharmacology·Pablo Torres-VergaraJeffrey Penny
Dec 29, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Magdalena GajęckaMaciej Gajęcki
Sep 18, 2020·International Journal of Molecular Sciences·Yuliya A PustylnyakVladimir O Pustylnyak
Apr 11, 2019·Frontiers in Bioengineering and Biotechnology·Nisarg GohilVijai Singh
Apr 16, 2019·Frontiers in Endocrinology·Rosa LaurettaMarialuisa Appetecchia
Apr 7, 2019·Mucosal Immunology·Mei Lan ChenMark S Sundrud
Nov 3, 2017·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Yuki YamasakiKan Chiba
Jun 20, 2018·International Journal of Molecular Sciences·Jurjen Duintjer TebbensPetr Pávek
Jun 13, 2020·International Journal of Molecular Sciences·Samantha C FaberMichael S Denison
Oct 21, 2020·Cells·Jenni KüblbeckPaavo Honkakoski
Sep 26, 2019·Chemico-biological Interactions·Clarissa Feltrin, Cláudia Maria Oliveira Simões
Nov 13, 2019·Toxicology·Eric Alejandro Rhon CalderónAlicia Graciela Faletti
Feb 23, 2021·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Jessica H HartmanJoel N Meyer
Jun 25, 2020·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Maria M BayliakVolodymyr I Lushchak
May 27, 2021·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Lena C PreissCarl Petersson
Jul 18, 2019·ACS Medicinal Chemistry Letters·Dongdong LiangHongbing Wang
Dec 24, 2021·American Journal of Physiology. Gastrointestinal and Liver Physiology·Kristoff M NievesKyle L Flannigan

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