Jun 26, 2012

Mechanisms regulating regional localization of inflammation during CNS autoimmunity

Immunological Reviews
Emily PiersonJoan M Goverman

Abstract

Multiple sclerosis (MS) is a disease of the central nervous system (CNS) characterized by inflammatory, demyelinating lesions localized in the brain and spinal cord. Experimental autoimmune encephalomyelitis (EAE) is an animal model of MS that is induced by activating myelin-specific T cells and exhibits immune cell infiltrates in the CNS similar to those seen in MS. Both MS and EAE exhibit disease heterogeneity, reflecting variations in clinical course and localization of lesions within the CNS. Collectively, the differences seen in MS and EAE suggest that the brain and spinal cord function as unique microenvironments that respond differently to infiltrating immune cells. This review addresses the roles of the cytokines interferon-γ and interleukin-17 in determining the localization of inflammation to the brain or spinal cord in EAE.

Mentioned in this Paper

Establishment and Maintenance of Localization
T-Lymphocyte
Myelin Sheath
Malignant Neoplasm of Spinal Cord
Cell Microenvironment
Brain
Human leukocyte interferon
Experimental Autoimmune Encephalomyelitis
Recombinant Interleukin-17
Neoplasm of Uncertain or Unknown Behavior of Spinal Cord

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

Nature Reviews. Immunology
Christopher B WilsonMasayuki Sekimata
Current Opinion in Immunology
Brigitta Stockinger, Marc Veldhoen
© 2020 Meta ULC. All rights reserved