Jun 26, 2012

Mechanisms regulating regional localization of inflammation during CNS autoimmunity

Immunological Reviews
Emily PiersonJoan M Goverman


Multiple sclerosis (MS) is a disease of the central nervous system (CNS) characterized by inflammatory, demyelinating lesions localized in the brain and spinal cord. Experimental autoimmune encephalomyelitis (EAE) is an animal model of MS that is induced by activating myelin-specific T cells and exhibits immune cell infiltrates in the CNS similar to those seen in MS. Both MS and EAE exhibit disease heterogeneity, reflecting variations in clinical course and localization of lesions within the CNS. Collectively, the differences seen in MS and EAE suggest that the brain and spinal cord function as unique microenvironments that respond differently to infiltrating immune cells. This review addresses the roles of the cytokines interferon-γ and interleukin-17 in determining the localization of inflammation to the brain or spinal cord in EAE.

Mentioned in this Paper

Establishment and Maintenance of Localization
Myelin Sheath
Malignant Neoplasm of Spinal Cord
Cell Microenvironment
Human leukocyte interferon
Experimental Autoimmune Encephalomyelitis
Recombinant Interleukin-17
Neoplasm of Uncertain or Unknown Behavior of Spinal Cord

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