Mechanisms regulating tumor angiogenesis by 12-lipoxygenase in prostate cancer cells

The Journal of Biological Chemistry
D NieK V Honn

Abstract

12-Lipoxygenase utilizes arachidonic acid to synthesize 12(S)-hydroperoxyeicosatetraenoic acid, which is converted to the end product 12(S)-hydroxyeicosatetraenoic acid, an eicosanoid that promotes tumorigenesis and metastasis. Increased expression of 12-lipoxygenase has been documented in a number of carcinomas. When overexpressed in human prostate or breast cancer, 12-lipoxygenase promotes tumor angiogenesis and growth in vivo. The present study was undertaken to delineate the mechanisms by which 12-lipoxygenase enhances angiogenesis. Herein we report that nordihydroguaiaretic acid, a pan inhibitor of lipoxygenases and baicalein, a selective inhibitor of 12-lipoxygenase, reduced VEGF expression in human prostate cancer PC-3 cells. Overexpression of 12-lipoxygenase in PC-3 cells resulted in a 3-fold increase in VEGF protein level when compared with vector control cells. An increase in PI 3-kinase activity was found in 12-LOX-transfected PC-3 cells and inhibition of PI 3-kinase by LY294002 significantly reduced VEGF expression. Northern blot and real time PCR analyses revealed an elevated VEGF transcript level in PC-3 cells transfected with a 12-lipoxygenase expression construct. Using a VEGF promoter luciferase construct (-117...Continue Reading

References

Jun 15, 1995·Biochemical and Biophysical Research Communications·D G TangK V Honn
Dec 1, 1994·Cancer Metastasis Reviews·K V HonnW Hagmann
May 28, 1996·Proceedings of the National Academy of Sciences of the United States of America·D G TangK V Honn
Sep 1, 1996·Molecular and Cellular Biology·J A ForsytheG L Semenza
Jun 6, 1998·Proceedings of the National Academy of Sciences of the United States of America·Y E WhangC L Sawyers
Jun 9, 1998·Frontiers in Bioscience : a Journal and Virtual Library·R Natarajan, J Nadler
Oct 13, 1998·Current Biology : CB·M M ChouA Toker
Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·X WuC L Sawyers
Mar 31, 2000·Nature Medicine·P Carmeliet
Aug 31, 2000·Biochemical and Biophysical Research Communications·C K SzekeresK V Honn
Nov 2, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M RomanoA Procopio
Mar 16, 2002·The Cancer Journal·Vinay K GuptaRalph R Weichselbaum
Mar 21, 2002·Nature Reviews. Cancer·Adrian L Harris
Oct 3, 2002·Nature Reviews. Cancer·Napoleone Ferrara
Apr 25, 2003·International Journal of Cancer. Journal International Du Cancer·Graham P PidgeonKenneth V Honn
Jun 5, 2003·Nature Reviews. Cancer·Gabriele Bergers, Laura E Benjamin
Jun 5, 2003·Nature Medicine·Napoleone FerraraJennifer LeCouter
Sep 29, 2004·Cytokine & Growth Factor Reviews·Keping XieSuyun Huang
Jan 8, 2005·Clinical Prostate Cancer·Primo N LaraDavid I Quinn
Jan 25, 2005·Cardiovascular Research·Gilles Pagès, Jacques Pouysségur
May 11, 2005·Cancer Letters·Kasem NithipatikomWilliam B Campbell

❮ Previous
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Citations

Oct 19, 2007·Cancer Metastasis Reviews·Graham P PidgeonKenneth V Honn
Oct 18, 2011·Cancer Metastasis Reviews·Claus Schneider, Ambra Pozzi
Jun 11, 2008·Clinical & Experimental Metastasis·Sarah Jane LuntRichard P Hill
Oct 31, 2013·Journal of Mammary Gland Biology and Neoplasia·Linda Vona-Davis, David P Rose
Oct 1, 2010·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Jorn-Hon LiuHsiao-Ming Chao
Feb 26, 2010·Cardiovascular Research·Daniël G M MolinMark J Post
Oct 17, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Anton PekcecKlaus van Leyen
Feb 29, 2008·Journal of Lipid Research·Igor A Butovich, Svetlana M Lukyanova
Feb 27, 2009·Journal of Lipid Research·Matthew W BuczynskiEdward A Dennis
Aug 1, 2008·Future Lipidology·Kasem Nithipatikom, William B Campbell
Jan 22, 2011·Experimental & Molecular Medicine·Ji Min SeoJae Hong Kim
May 3, 2014·Journal of Pharmaceutical and Biomedical Analysis·Isabella SquellerioViviana Cavalca
May 29, 2010·Cellular and Molecular Life Sciences : CMLS·Wan-Chen HuangBen-Kuen Chen
Aug 7, 2012·Familial Cancer·Vidudala V T S Prasad, Kolli Padma
Feb 9, 2016·Seminars in Cancer Biology·Nagendra Sastry YarlaGovinda Rao Duddukuri
Oct 27, 2009·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Jingyan WeiHsin-Hsiung Tai
Sep 23, 2008·Experimental Cell Research·Napoleon Navarro-TitoEduardo Perez Salazar
Sep 14, 2010·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Ambra Pozzi, Roy Zent
Dec 18, 2008·International Journal of Cancer. Journal International Du Cancer·Yong TangDaotai Nie
Feb 26, 2008·British Journal of Pharmacology·D SodiniF Coceani
Mar 26, 2013·International Journal of Cancer. Journal International Du Cancer·Ashok-kumar DillyKenneth V Honn
Mar 17, 2010·BioFactors·Rocío de la IglesiaJ Alfredo Martínez
Apr 11, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Fon-Chang LiuChieh-Hsi Wu
Aug 8, 2014·Blood·Jennifer YeungMichael Holinstat
Sep 12, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Manoj KumarD K Dhawan
Oct 13, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jeffrey C BemisThomas A Gasiewicz
Apr 2, 2014·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Benedetta PorroViviana Cavalca
Oct 10, 2009·Integrative Cancer Therapies·Gazala N KhanSofia D Merajver
Aug 6, 2018·Cancer Metastasis Reviews·Athanassios A PanagiotopoulosMarilena Kampa
Mar 17, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Geun-Young KimJae-Hong Kim
Apr 23, 2008·Molecular Pharmacology·Hyunju ChoEun Gyeong Yang
Mar 12, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kenneth V HonnStephanie C Tucker

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