Mechanisms responsible for increased circulating levels of galectin-3 in cardiomyopathy and heart failure

Scientific Reports
My-Nhan NguyenXiao-Jun Du

Abstract

Galectin-3 is a biomarker of heart disease. However, it remains unknown whether increase in galectin-3 levels is dependent on aetiology or disease-associated conditions and whether diseased heart releases galectin-3 into the circulation. We explored these questions in mouse models of heart disease and in patients with cardiomyopathy. All mouse models (dilated cardiomyopathy, DCM; fibrotic cardiomyopathy, ischemia-reperfusion, I/R; treatment with β-adrenergic agonist isoproterenol) showed multi-fold increases in cardiac galectin-3 expression and preserved renal function. In mice with fibrotic cardiomyopathy, I/R or isoproterenol treatment, plasma galectin-3 levels and density of cardiac inflammatory cells were elevated. These models also exhibited parallel changes in cardiac and plasma galectin-3 levels and presence of trans-cardiac galectin-3 gradient, indicating cardiac release of galectin-3. DCM mice showed no change in circulating galectin-3 levels nor trans-cardiac galectin-3 gradient or myocardial inflammatory infiltration despite a 50-fold increase in cardiac galectin-3 content. In patients with hypertrophic cardiomyopathy or DCM, plasma galectin-3 increased only in those with renal dysfunction and a trans-cardiac galecti...Continue Reading

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Citations

Dec 5, 2018·Biomarkers in Medicine·Evangelos OikonomouDimitris Tousoulis
Nov 6, 2018·American Journal of Physiology. Heart and Circulatory Physiology·My-Nhan NguyenXiao-Jun Du
Feb 14, 2019·British Journal of Pharmacology·Xiao-Jun DuHelen Kiriazis
Oct 11, 2019·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Xi ZhangChamindie Punyadeera
Dec 7, 2020·Clinical Chemistry·Eugene S J TanArthur M Richards
Nov 14, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Shingo TakaharaJason R B Dyck
Dec 9, 2020·International Journal of Molecular Sciences·Valeria BlandaGiuliana Fortunato
Apr 16, 2021·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Marco CasonKalliopi Pilichou
Oct 6, 2020·Aging and Disease·Yuejia DingJunping Zhang

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Methods Mentioned

BETA
transgenic
biopsies
ELISA

Software Mentioned

SigmaStat
ARRIVE
Prism
ImageJ
AnalySIS FIVE

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