PMID: 6981812Jul 1, 1982Paper

Mechanisms that uncouple growth and differentiation in myeloid leukemia cells: restoration of requirement for normal growth-inducing protein without restoring induction of differentiation-inducing protein

Proceedings of the National Academy of Sciences of the United States of America
J Lotem, L Sachs

Abstract

There are different macrophage- and granulocyte-inducing (MGI) proteins. Normal myeloid precursors are induced to multiply by one form (MGI-1) and to differentiate by another form (MGI-2). There are clones of myeloid leukemia cells that no longer require MGI-1 for growth but can still be induced to differentiate by MGI-2. After induction of differentiation in these leukemia cells by adding MCI-2 or inducing endogenous production of MGI-2 by lipopolysaccharide, the differentiating leukemia cells, like normal cells, again required MGI-1 for growth. This growth requirement for MGI-1 could not be substituted for by adding other protein growth factors such as epidermal, fibroblast, or nerve growth factor or insulin. Induction of differentiation in these leukemia cells by dexamethasone, arabinonucleoside (cytosine arabinoside), or methotrexate instead of by MGI-2, did not restore the requirement of MGI-1 for growth. Mutant myeloid leukemia cells that could not be induced to differentiate by MGI-2 also did not show this restoration of the requirement of MGI-1 for growth. MGI-1 in normal cells induced cell growth and also induced MGI-2, so that the cells could then differentiate by the endogenously produced MGI-2. However, MGI-1 did no...Continue Reading

References

Jul 1, 1978·The Journal of Experimental Medicine·A Granelli-Piperno, E Reich
Jul 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·D Liebermann, L Sachs
Jan 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·J I Azumi, L Sachs
Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·J Lotem, L Sachs
Mar 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·B Weiss, L Sachs
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Jan 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·J I Toohey
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Oct 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·T Landau, L Sachs
Feb 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·E FibachL Sachs
Sep 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·J Lotem, L Sachs
Aug 1, 1966·Proceedings of the National Academy of Sciences of the United States of America·Y IchikawaL Sachs
Oct 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·Y IchikawaL Sachs
Dec 1, 1965·Journal of Cellular Physiology·D H Pluznik, L Sachs
Nov 15, 1980·International Journal of Cancer. Journal International Du Cancer·A Falk, L Sachs
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Jan 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·L Cohen, L Sachs
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Jun 15, 1980·International Journal of Cancer. Journal International Du Cancer·J LotemL Sachs

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Citations

Jan 1, 1984·Cancer Metastasis Reviews·M G BrattainB Long
Jan 1, 1988·The International Journal of Biochemistry·L C OlsenI F Pryme
Aug 23, 2002·Seminars in Cancer Biology·Joseph Lotem, Leo Sachs
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·R E Scott, P B Maercklein
May 14, 1996·Proceedings of the National Academy of Sciences of the United States of America·L Sachs
Apr 1, 1984·Food Additives and Contaminants·P E Fournier, G Thomas
Jan 29, 2014·Proceedings of the National Academy of Sciences of the United States of America·Michael Sela, Yoram Groner
Jan 10, 2004·Toxicologic Pathology·Silke BurkhardtManfred Reinacher
Aug 21, 1987·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·L Sachs
Nov 5, 1984·Nature·L Sachs, J Lotem
Dec 1, 1986·Cell Biophysics·L Sachs
Jan 15, 1988·International Journal of Cancer. Journal International Du Cancer·J LotemL Sachs
Oct 15, 1987·International Journal of Cancer. Journal International Du Cancer·J Lotem, L Sachs
Jan 15, 1984·International Journal of Cancer. Journal International Du Cancer·J Lotem, L Sachs
Dec 15, 1983·International Journal of Cancer. Journal International Du Cancer·J Lotem, L Sachs
Jul 15, 1983·International Journal of Cancer. Journal International Du Cancer·J Lotem, L Sachs
Jan 15, 1985·International Journal of Cancer. Journal International Du Cancer·J Lotem, L Sachs
Jan 1, 1989·Annals of the New York Academy of Sciences·L SachsY Shabo

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