Mechanisms underlying regional differences in lipolysis in human adipose tissue

The Journal of Clinical Investigation
H WahrenbergP Arner

Abstract

Catecholamine-induced lipolysis was investigated in nonobese females and males. Isolated subcutaneous adipocytes were obtained from the abdominal and gluteal regions. The lipolytic effect of noradrenaline was four to fivefold more marked in abdominal adipocytes than in gluteal fat cells. This regional difference was more apparent in females than in males. No site differences were observed when lipolysis was stimulated with agents acting at different postreceptor levels. The beta-adrenergic lipolytic sensitivity was 10-20 times greater in abdominal adipocytes from both sexes than in gluteal adipocytes. Abdominal adipocytes from females showed a 40 times lower alpha 2-adrenergic antilipolytic sensitivity than did gluteal adipocytes, but the adenosine receptor sensitivity was similar in both sites. Beta-receptor affinity for agonists displayed no site or sex variation. Abdominal adipocytes showed a twofold increased beta-adrenoceptor density than did gluteal cells from both sexes. The alpha 2-adrenoceptor density was similar in all regions, but in females the affinity of clonidine for these sites was 10-15 times lower in the abdominal fat cells compared with gluteal cells. In conclusion, regional differences in catecholamine-induc...Continue Reading

References

Oct 1, 1979·European Journal of Clinical Investigation·U SmithJ G Kral
Dec 1, 1977·European Journal of Clinical Investigation·H KatherG Schlierf
Jan 27, 1988·European Journal of Pharmacology·P ArnerP Engfeldt
Jun 1, 1987·The Journal of Clinical Investigation·C MarcusP Arner
Jan 1, 1987·Annual Review of Biochemistry·A G Gilman
Nov 1, 1988·The Journal of Clinical Investigation·C MarcusP Arner
Jul 1, 1988·Acta Endocrinologica·S StonehamJ J Ohisalo
Jun 1, 1987·The Journal of Clinical Endocrinology and Metabolism·R L Leibel, J Hirsch
Jan 1, 1984·The Journal of Clinical Investigation·A G Gilman
Sep 1, 1980·Analytical Biochemistry·P J Munson, D Rodbard
Jun 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·K B SeamonJ W Daly
Aug 1, 1983·The Journal of Clinical Endocrinology and Metabolism·D J EvansA H Kissebah
Sep 1, 1983·The Journal of Clinical Investigation·M KrotkiewskiU Smith

❮ Previous
Next ❯

Citations

May 11, 2004·Current Diabetes Reports·Mandeep Bajaj, Mary Ann Banerji
Apr 1, 1992·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·R Van den BerghS E Terblanche
Oct 1, 1992·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·M van de VenterW Oelofsen
Jul 4, 2012·Molecular and Cellular Endocrinology·Yonit MarcusNaftali Stern
Feb 23, 2005·Nutrition·John L ZenkMichael A Kuskowski
Aug 1, 1997·Molecular Aspects of Medicine·E Jéquir, L Tappy
Sep 1, 1996·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·T L GilsonT Rampersand
Oct 1, 1993·Baillière's Clinical Endocrinology and Metabolism·L C Groop, E Ferrannini
Oct 1, 2003·Trends in Endocrinology and Metabolism : TEM·Jeffrey F Horowitz
Dec 15, 2010·The Proceedings of the Nutrition Society·Katherine E Pinnick, Fredrik Karpe
Jan 13, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·K N ManolopoulosK N Frayn
Mar 11, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M NourshahiE Ernst
Jun 20, 2001·Diabetes, Obesity & Metabolism·A J Stears, C D Byrne
May 8, 1998·The Proceedings of the Nutrition Society·W H Martin, S Klein
Jun 12, 1998·Plastic and Reconstructive Surgery·M RosenbaumA G Ship
Oct 1, 1991·European Journal of Clinical Investigation·H WahrenbergP Arner
Jun 1, 1992·European Journal of Clinical Investigation·H WahrenbergP Arner
Jan 16, 2007·Molecular and Cellular Biology·Hao YingSheue-Yann Cheng
Jan 1, 1997·Annual Review of Nutrition·M D Jensen
May 18, 2007·Annual Review of Nutrition·Susanne B Votruba, Michael D Jensen
Jul 13, 2006·American Journal of Physiology. Endocrinology and Metabolism·James P WarneJulia C Buckingham
May 1, 1990·The Journal of Clinical Investigation·F LönnqvistP Arner
Nov 1, 1990·The Journal of Clinical Investigation·P ArnerM Brönnegård
Aug 1, 1991·The Journal of Clinical Investigation·M L Martin, M D Jensen
Dec 1, 1992·The Journal of Clinical Investigation·F LönnqvistP Arner
Nov 1, 1995·The Journal of Clinical Investigation·M D Jensen
Aug 1, 1996·The Journal of Clinical Investigation·S W CoppackJ M Miles
Jun 2, 2012·Biology of Sex Differences·Kalypso KarastergiouSusan K Fried
May 12, 2005·The Journal of Clinical Endocrinology and Metabolism·R E Van PeltW M Kohrt
Jan 4, 2007·The Journal of Clinical Endocrinology and Metabolism·Leanne M RedmanUNKNOWN Pennington CALERIE Team
Nov 15, 2012·The Journal of Clinical Endocrinology and Metabolism·Kalypso KarastergiouSteven R Smith
May 3, 2014·PloS One·Hyung Sun YooJianhua Shao
Jun 26, 2012·Journal of Strength and Conditioning Research·Gabriel M HögströmAnna Nordström
Jan 26, 2011·European Journal of Histochemistry : EJH·A SbarbatiP Panettiere
Sep 5, 2013·Thyroid : Official Journal of the American Thyroid Association·Antonio C BiancoUNKNOWN American Thyroid Association Task Force on Approaches and Strategies to Investigate Thyroid Hormone Economy and Action
Sep 18, 1998·Sports Medicine·R F Ranallo, E C Rhodes
Apr 9, 2004·The Proceedings of the Nutrition Society·Christine M Williams
Jan 18, 2006·Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology·Adam M RotundaAlison Sharpe Avram
Jun 15, 2007·Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology·Gordon H SasakiMargaret Gaston

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.