Mechanisms underlying skeletal muscle weakness in human heart failure: alterations in single fiber myosin protein content and function.

Circulation. Heart Failure
Mark S MillerMichael J Toth

Abstract

Patients with chronic heart failure (HF) frequently experience skeletal muscle weakness that limits physical function. The mechanisms underlying muscle weakness, however, have not been clearly defined. This study examined the hypothesis that HF promotes a loss of myosin protein from single skeletal muscle fibers, which in turn reduces contractile performance. Ten patients with chronic HF and 10 controls were studied. Muscle atrophy was not evident in patients, and groups displayed similar physical activity levels, suggesting that observed differences reflect the effects of HF and not muscle atrophy or disuse. In single muscle fibers, patients with HF showed reduced myosin heavy chain protein content (P<0.05) that manifested as a reduction in functional myosin-actin cross-bridges (P<0.05). No evidence was found for a generalized loss of myofilament protein, suggesting a selective loss of myosin. Accordingly, single muscle fiber maximal Ca(2+)-activated tension was reduced in myosin heavy chain I fibers in patients (P<0.05). However, tension was maintained in myosin heavy chain IIA fibers in patients because a greater proportion of available myosin heads were bound to actin during Ca(2+) activation (P<0.01). Collectively, our res...Continue Reading

References

May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·B Brenner
Oct 27, 1988·Nature·L C RomeM Freadman
Jan 5, 1987·Journal of Molecular Biology·R D BallB Alizadeh
Mar 14, 1985·Nature·R Hennig, T Lømo
Sep 1, 1985·Archives of Internal Medicine·W A NeillS Osberg
Jul 25, 1983·Journal of Molecular Biology·L D Yates, M L Greaser
Oct 1, 1993·Journal of the American College of Cardiology·J R Wilson, D M Mancini
Jul 1, 1993·Journal of the American College of Cardiology·K P Anderson
May 1, 1997·The American Journal of Cardiology·M J TothE T Poehlman
Jul 1, 1997·Medicine and Science in Sports and Exercise·M J SullivanB Saltin
Dec 31, 1997·Journal of the American College of Cardiology·D HarringtonA J Coats
Jun 23, 1998·Journal of Muscle Research and Cell Motility·K Hilber, S Galler
Aug 5, 2000·Journal of Applied Physiology·P C GeigerG C Sieck
Jun 19, 2001·American Journal of Physiology. Endocrinology and Metabolism·M J TothE T Poehlman
Oct 5, 2001·Journal of the American College of Cardiology·B MettauerR Ventura-Clapier
Nov 3, 2001·Pflügers Archiv : European journal of physiology·R Bottinelli
Aug 6, 2003·Medicine and Science in Sports and Exercise·Philip A AdesEric T Poehlman
Oct 17, 2003·The Journal of Physiology·Giuseppe D'AntonaRoberto Bottinelli
Nov 6, 2003·Journal of Applied Physiology·Gregory R AdamsKenneth M Baldwin
Aug 3, 2004·The Journal of Clinical Investigation·Swarnali AcharyyaDenis C Guttridge
Nov 25, 2004·American Journal of Physiology. Endocrinology and Metabolism·Michael J TothMartin M LeWinter
Apr 30, 2005·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Marjolein VisserTamara B Harris
Sep 6, 2005·Journal of Applied Physiology·Michael J TothAndré Tchernof
Jan 18, 2006·International Journal of Cardiology·Michael J TothMartin M LeWinter
Apr 24, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Hieronymus W H van HeesP N Richard Dekhuijzen
Jan 19, 2008·Journal of Applied Physiology·Yoko OkadaPeter Vanburen
Apr 22, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Hieronymus W H van HeesLeo M A Heunks
Mar 31, 2009·International Journal of Cardiology·Michael J TothPhilip A Ades

❮ Previous
Next ❯

Citations

Jul 14, 2010·Journal of Biomedicine & Biotechnology·Mark S MillerJim O Vigoreaux
Jan 15, 2011·Medicine and Science in Sports and Exercise·Patrick A SavageMichael J Toth
Nov 30, 2014·Heart Failure Clinics·Leonard A Kaminsky, Mary S Tuttle
Oct 16, 2012·Heart Failure Reviews·Cynthia Zizola, P Christian Schulze
Jun 11, 2015·Muscle & Nerve·Jason L RengoMichael J Toth
Mar 25, 2016·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Michael J TothKim Dittus
Dec 16, 2010·European Journal of Clinical Investigation·Danny AlexanderAli J Marian
Nov 22, 2011·Journal of Molecular and Cellular Cardiology·Andrea SchrepperTorsten Doenst
Jun 9, 2016·Current Heart Failure Reports·Andrew R Coggan, Linda R Peterson
Mar 18, 2017·Journal of Cardiopulmonary Rehabilitation and Prevention·Jason L RengoPhilip A Ades
Aug 21, 2010·The Journal of Physiology·Mark S MillerMichael J Toth
Dec 12, 2012·Current Opinion in Clinical Nutrition and Metabolic Care·Damien M Callahan, Michael J Toth
Mar 27, 2015·American Journal of Physiology. Cell Physiology·Damien M CallahanMichael J Toth
Feb 23, 2019·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Sara Y OikawaStuart M Phillips
Nov 15, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Chad R StraightMark S Miller
Sep 22, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·T Scott BowenVolker Adams
Jun 4, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Chad R StraightMark S Miller
Feb 9, 2013·Exercise and Sport Sciences Reviews·Mark S Miller, Michael J Toth
Jan 29, 2011·Journal of Applied Physiology·Kyle L Timmerman, Blake B Rasmussen
Mar 9, 2019·Frontiers in Physiology·Manda L Keller-RossBruce D Johnson
Jan 1, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·T Scott BowenVolker Adams
Aug 4, 2020·Current Heart Failure Reports·Anastassios PhilippouMichael Koutsilieris
Oct 21, 2020·Acta Neuropathologica Communications·Jacob A RossJulien Ochala
Dec 22, 2020·The Journal of Physiology·Ever Espino-GonzalezT Scott Bowen
Feb 11, 2021·Circulation Journal : Official Journal of the Japanese Circulation Society·Yasuhiro MatsudaToshiaki Mano
Jan 21, 2021·Biomolecules·Dina Aweida, Shenhav Cohen
Apr 18, 2018·American Journal of Lifestyle Medicine·Michael J LaMonte

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.