Mechanisms Underlying the Antidepressant Response of Acupuncture via PKA/CREB Signaling Pathway

Neural Plasticity
Huili JiangTuya Bao

Abstract

Protein kinase A (PKA)/cAMP response element-binding (CREB) protein signaling pathway, contributing to impaired neurogenesis parallel to depressive-like behaviors, has been identified as the crucial factor involved in the antidepressant response of acupuncture. However, the molecular mechanisms associated with antidepressant response of acupuncture, neurogenesis, and depressive-like behaviors ameliorating remain unexplored. The objective was to identify the mechanisms underlying the antidepressant response of acupuncture through PKA signaling pathway in depression rats by employing the PKA signaling pathway inhibitor H89 in in vivo experiments. Our results indicated that the expression of hippocampal PKA-αand p-CREB was significantly downregulated by chronic unpredicted mild stress (CUMS) procedures. Importantly, acupuncture reversed the downregulation of PKA-αand p-CREB. The expression of PKA-αwas upregulated by fluoxetine, but not p-CREB. No significant difference was found between Acu and FLX groups on the expression of PKA-αand p-CREB. Interestingly, H89 inhibited the effects of acupuncture or fluoxetine on upregulating the expression of p-CREB, but not PKA-α. There was no significant difference in expression of CREB among ...Continue Reading

References

Jan 1, 1981·Neuroscience and Biobehavioral Reviews·R J KatzB J Carroll
Dec 9, 1997·Neuron·S FinkbeinerM E Greenberg
Jun 29, 2000·Annual Review of Biochemistry·A J Shaywitz, M E Greenberg
Nov 7, 2000·Biological Psychiatry·R S DumanC D'Sa
Sep 24, 2002·Proceedings of the National Academy of Sciences of the United States of America·Ottavio V VitoloMichael Shelanski
Jun 19, 2003·JAMA : the Journal of the American Medical Association·Ronald C KesslerUNKNOWN National Comorbidity Survey Replication
Mar 12, 2004·Progress in Neurobiology·P V Nguyen, N H Woo
Oct 19, 2005·Neurobiology of Learning and Memory·Craig M Powell
Dec 1, 2005·Trends in Immunology·Charles L RaisonAndrew H Miller
Jul 18, 2006·Neurobiology of Disease·Sabine ChourbajiPeter Gass
Jan 12, 2007·Cardiovascular Drug Reviews·A Lochner, J A Moolman
Apr 3, 2008·The Journal of Biological Chemistry·Yuriko IwakuraMoses V Chao
Jul 10, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nicola Maggio, Menahem Segal
Nov 10, 2009·Journal of Traditional Chinese Medicine = Chung I Tsa Chih Ying Wen Pan·Dong-Mei DuanZheng-Jun Wu
Oct 19, 2010·Nature Medicine·Vanja DuricRonald S Duman
Aug 15, 2012·Proceedings of the National Academy of Sciences of the United States of America·Yao HuDong-Ya Zhu
Sep 29, 2012·Behavioural Brain Research·Andiara E FreitasAna Lúcia S Rodrigues
Oct 10, 2012·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Sophia L B OliveiraHenning Ulrich
Jul 12, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Jun LuJian-You Guo
Oct 30, 2013·The Journal of Cell Biology·Nathalia Vitureira, Yukiko Goda
Nov 8, 2013·Frontiers in Systems Neuroscience·Edmund T Rolls
Dec 7, 2013·Frontiers in Cellular Neuroscience·Shawn Hayley, Darcy Litteljohn
Apr 19, 2015·Trends in Neurosciences·Scott M ThompsonXiang Cai
Jul 28, 2015·Scientific Reports·Won-Mo JungYounbyoung Chae
Sep 30, 2016·BMC Complementary and Alternative Medicine·Xuhui ZhangBingcong Zhao

❮ Previous
Next ❯

Citations

Nov 8, 2017·Neuromodulation : Journal of the International Neuromodulation Society·Ling-Yong XiaoCun-Zhi Liu
Dec 15, 2019·Clinical and Experimental Pharmacology & Physiology·Lihong ZhaoBingjin Li
Jan 14, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Jun ZhaoZhigang Li
Aug 6, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Hsiang-Chun LaiChing-Liang Hsieh
Aug 30, 2019·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Xiao-Shuang WangDe-Shou Wang
Dec 22, 2020·Frontiers in Behavioral Neuroscience·Lu BaiLong Wang
Aug 26, 2021·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Xiang LiHui-Li Jiang

❮ Previous
Next ❯

Methods Mentioned

BETA
electrophoresis

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.