Mechanisms underlying the gastroprotective action of glucocorticoids released in response to ulcerogenic stress factors

Annals of the New York Academy of Sciences
Ludmila FilaretovaKoji Takeuchi

Abstract

Our previous results demonstrate the gastroprotective but not ulcerogenic action of glucocorticoids released in response to ulcerogenic stress factors. The present study was undertaken to investigate the possible mechanisms underlying the gastroprotective action of glucocorticoids in rat stomachs. The effects of deficiency of glucocorticoid production, with or without corticosterone supplementation, on blood flow velocity in gastric microvessels, microvascular permeability, mucus production, motility as well as gastric lesions were studied 3 to 4 h after the onset of ulcerogenic stimuli: water-restraint stress or indomethacin administration. The contribution of glucocorticoids in the healing process of gastric injury was also evaluated. The deficiency in glucocorticoid production significantly potentiated the functional disorders induced by ulcerogenic stimuli, such as a decrease in blood flow velocity and mucus production and an increase in gastric motility and in microvascular permeability, which resulted in aggravation of the formation of gastric lesions as well as impairment of their healing. The changes observed were prevented by supplementation of corticosterone at a dose mimicking a stress-induced corticosterone rise. We...Continue Reading

Citations

Nov 2, 2005·Inflammopharmacology·L P FilaretovaK Takeuchi
Sep 1, 2011·Therapeutic Advances in Chronic Disease·Ludmila Filaretova
May 7, 2014·The Journal of Physiological Sciences : JPS·V Nimet Izgüt-UysalIsmail Üstünel
Oct 16, 2012·Digestive Diseases and Sciences·Charles P KoczkaAdam J Goodman
Apr 3, 2008·Clinical Biochemistry·Bariş KoşanEmin Altiparmak
Jun 30, 2007·Journal of Pharmacological Sciences·Ludmila FilaretovaKoji Takeuchi
Dec 8, 2016·Stress : the International Journal on the Biology of Stress·Liang WangZhaofan Xia
May 11, 2005·World Journal of Gastroenterology : WJG·Ping JiangChao-Shu Tang
Sep 9, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Hitomi SeinoHaruki Okamura
Dec 1, 2010·Molecular and Cellular Biochemistry·S I ChandranathJ Singh
Oct 11, 2017·Molecular Medicine Reports·Ziqiang ZhangJianjun Du

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