Mechanisms underlying the morning increase in platelet aggregation: a flow cytometry study

Journal of the American College of Cardiology
N P AndrewsA A Quyyumi

Abstract

Mechanisms underlying the morning increase in platelet aggregation produced by arising and assuming the upright posture were studied by examining 1) the expression on the platelet surface of activation-dependent markers; 2) platelet aggregation in whole blood; and 3) hematologic factors likely to influence aggregation. The morning increase in thrombotic cardiovascular events has been attributed, in part, to the morning surge in platelet aggregability, but its mechanisms are poorly understood. Expression of seven platelet surface antigens (including P-selectin, activated GPIIb,IIIa and GPIb-IX), whole-blood platelet aggregation, platelet count and hematocrit were measured before and after arising in 17 normal volunteers. The fibrinolytic variables, tissue-type plasminogen activator, plasminogen activator inhibitor 1 and catecholamine levels were also measured. On arising and standing, platelet aggregation increased by 71% (p < 0.01) and 27% (p < 0.03) in response to collagen and adenosine diphosphate, respectively. However, there was no change in any of the activation-dependent platelet surface markers. Whole-blood platelet count and hematocrit increased by 15% and 7% (both p < 0.0001), respectively. Norepinephrine and epinephri...Continue Reading

References

Jan 1, 1979·Thrombosis Research·C M IngermanM J Silver
Oct 1, 1975·British Journal of Haematology·M L Freedman, S Karpatkin
Dec 1, 1992·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·H TakahashiA Shibata
Apr 1, 1992·The American Journal of Cardiology·S M JafriS Goldstein
Apr 1, 1989·Stroke; a Journal of Cerebral Circulation·J R MarlerM A Foulkes
Nov 21, 1985·The New England Journal of Medicine·J E MullerT Robertson
Oct 1, 1987·The American Journal of Cardiology·S N WillichJ E Muller
Dec 31, 1987·The New England Journal of Medicine·H A Payne
Jan 1, 1974·Acta Haematologica·C P Warlow, D Ogston
Oct 27, 1984·Lancet·M J HarrisonE Weisblatt
Feb 1, 1980·Journal of Pharmacological Methods·D C Cardinal, R J Flower
Jan 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·P HjemdahlA H Goodall
Mar 15, 1994·Thrombosis Research·K F KofoedK Winther
Oct 1, 1993·Circulation·A S KestinA D Michelson

❮ Previous
Next ❯

Citations

Nov 29, 2005·Molecular and Cellular Biochemistry·Hatice Aldemir, Nedret Kiliç
May 27, 2003·American Heart Journal·Yi-Fang Guo, Phyllis K Stein
Aug 30, 2003·Brain, Behavior, and Immunity·Michael IrwinMichael Ziegler
May 8, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Norihiko Takeda, Koji Maemura
Sep 30, 2003·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·William B White
Feb 12, 2004·Journal of Cardiovascular Pharmacology·Kazuomi KarioThomas G Pickering
Sep 24, 2010·Coronary Artery Disease·Vladimir Slavisa IgnjatovicSlavisa Ignjatovic
Aug 24, 1999·Pharmacotherapy·B E BleskeJ M Nicklas
Oct 10, 2012·Neurología : publicación oficial de la Sociedad Española de Neurología·J VivancosJ Tejada
Jun 20, 2002·Journal of Pineal Research·Mabel Y C YauStephen Y W Shiu
Mar 2, 2011·Current Problems in Cardiology·Karim D MahmoudDavid R Holmes
Nov 1, 2008·Journal of the American Society of Hypertension : JASH·Kazuomi Kario, William B White
Apr 25, 2008·Thrombosis Research·Naoki OhkuraShuichi Horie
Jan 24, 2007·Journal of Thrombosis and Haemostasis : JTH·G VilahurJ J Badimon
Jun 2, 2011·Platelets·Marek KozinskiJacek Kubica
Jun 3, 2015·The Canadian Journal of Cardiology·Faisal J AlibhaiTami A Martino
Aug 28, 2014·Frontiers in Neurology·Anke WoutersVincent Thijs
May 24, 2016·Translational Stroke Research·Joel N SwerdelUNKNOWN Myocardial Infarction Data Acquisition System (MIDAS 27) Study Group
May 11, 2010·Advanced Drug Delivery Reviews·Norihiko Takeda, Koji Maemura
Nov 23, 2005·Current Problems in Cardiology·Robert WolkVirend K Somers
Aug 20, 2015·The Neurohospitalist·Mark N Rubin, Kevin M Barrett
Nov 21, 2009·Circulation Research·Tami A Martino, Michael J Sole
Sep 13, 2019·CNS Spectrums·Mohamed ElfilBrian B Koo
Jun 25, 2020·Pacing and Clinical Electrophysiology : PACE·Arwa YounisMehmet K Aktas
Mar 19, 2004·Clinical Science·Roland von KänelJoachim E Fischer
Apr 15, 2015·Journal of Cardiovascular Pharmacology and Therapeutics·Vladimir IgnjatovicJelena Nesic
Jul 3, 2021·Brain Sciences·Dana Marieta FodorLăcrămioara Perju-Dumbravă

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.