Mechanisms with clinical implications for atrial fibrillation-associated remodeling: cathepsin K expression, regulation, and therapeutic target and biomarker

Journal of the American Heart Association
Masaya FujitaToyoaki Murohara

Abstract

The cysteine protease cathepsin K (CatK) has been implicated in the pathogenesis of cardiovascular disease. We sought to determine the link between atrial fibrillation (AF) and plasma CatK levels and to investigate the expression of and therapeutic target for CatK in vivo and in vitro. Plasma CatK and extracellular matrix protein peptides (intact procollagen type I of N-terminal propeptide; carboxyl-terminal telopeptide of type I collagen [ICTP]) were measured in 209 consecutive patients with AF (paroxysmal AF, 146; persistent AF, 63) and 112 control subjects. In addition, the regulation of CatK expression was investigated in vivo and vitro. Patients with AF had higher plasma CatK and ICTP levels than did control subjects. Patients with persistent AF had higher levels of plasma CatK and ICTP than did patients with paroxysmal AF. CatK was correlated with ICTP concentration and left atrial diameter in all subjects. In rabbits, superoxide production, CatK activity, fibrosis, and the levels of atrial tissue angiotensin II, angiotensin type 1 receptor, gp91phox, phospho-p38 mitogen-activated protein kinase, and CatK were greater in those with tachypacing-induced AF than in controls, and these changes were reversed with angiotensin t...Continue Reading

References

Mar 10, 2000·Biochimica Et Biophysica Acta·B TurkV Turk
Oct 31, 2001·The British Journal of Surgery·J S LindholtE W Henneberg
Jun 14, 2002·Cardiovascular Research·Maurits AllessieUlrich Schotten
Mar 17, 2004·Circulation·Chia-Ti TsaiYung-Zu Tseng
Jun 7, 2005·Journal of the American College of Cardiology·Jeff S HealeyStuart J Connolly
Feb 13, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Erol SaygiliCarsten Zobel
Oct 19, 2007·The Journal of Biological Chemistry·Daniel SpiraThomas Reinheckel
Jul 12, 2008·Journal of the American College of Cardiology·Eleftherios M KallergisPanos E Vardas
Aug 19, 2009·Journal of Molecular and Cellular Cardiology·Gregory M FomovskyJeffrey W Holmes
Dec 15, 2010·Cardiovascular Research·Mei SunPeter P Liu
Jan 21, 2011·Physiological Reviews·Ulrich SchottenAndreas Goette
Oct 5, 2011·Arthritis and Rheumatism·Eiji KozawaNaoki Ishiguro
Feb 2, 2013·Atherosclerosis·Xian Wu ChengToyoaki Murohara

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Citations

Jan 23, 2016·Rheumatology·Roland D Chapurlat, Cyrille B Confavreux
Mar 9, 2017·Molecular Diagnosis & Therapy·Patrick Garnero
Aug 25, 2015·PloS One·Guangxian ZhaoXianwu Cheng
Jul 12, 2018·Interactive Cardiovascular and Thoracic Surgery·Ilias P DoulamisKonstantinos Perreas
Nov 28, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Eylem TaskinNurcan Dursun
Apr 22, 2018·Nature Reviews. Cardiology·Cong-Lin LiuGuo-Ping Shi
Feb 11, 2020·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Gordon A BeggMuzahir H Tayebjee
Jun 26, 2020·Frontiers in Cell and Developmental Biology·Rongchen DaiGe Zhang
Jan 12, 2020·Biochimica Et Biophysica Acta. Proteins and Proteomics·Xian ZhangGuo-Ping Shi
Jan 5, 2021·International Heart Journal·Chenglin YuXianwu Cheng

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Methods Mentioned

BETA
ELISA
PCR
ELISAs
nuclear translocation
gene knockout

Software Mentioned

BZ II Analyzer
Exe
StatFlex

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