PMID: 9548670Apr 21, 1998Paper

Mechanistic analysis of pancreatic ductal carcinogenesis in hamsters

Pancreas
Y KonishiT Tsujiuchi

Abstract

In this article, we introduce our rapid-production model for pancreatic duct adenocarcinomas and describe the mechanisms of pancreatic duct carcinogenesis so far elucidated in Syrian golden hamsters. It is evident that a series of histogenetic steps are involved, leading from hyperplasia through atypical hyperplasia to intraductal carcinoma and invasive carcinoma. As DNA alters, K-ras mutation appears to be an early event, whereas p53 mutations generally occur in the tumor-progression phase. The induced cancer cells may show autocrine growth, secreting TGF-alpha and vascular endothelial growth factor (VEGF), and are immortalized with a shortened TRF length and increased telomerase activity. The rapid-production model of pancreatic duct adenocarcinomas has not only provided a major stimulus to understanding induction mechanisms but should also serve as a bioassay to facilitate the identification of dietary risk factors and the search for appropriate chemopreventive or chemotherapeutic agents or both to help control this deadly disease.

Citations

Feb 21, 2002·Pancreas·Alexis B UlrichParviz M Pour
Jan 20, 2012·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Ingo GerhauserWolfgang Baumgärtner
Jan 19, 2019·Expert Opinion on Drug Discovery·Savita Bisht, Georg Feldmann
Apr 26, 2021·Advanced Drug Delivery Reviews·Marcel A HeinrichJai Prakash

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