Mechanistic analysis of Zein nanoparticles/PLGA triblock in situ forming implants for glimepiride

International Journal of Nanomedicine
Osama A A AhmedMaan Khayat

Abstract

The study aims at applying pharmaceutical nanotechnology and D-optimal fractional factorial design to screen and optimize the high-risk variables affecting the performance of a complex drug delivery system consisting of glimepiride-Zein nanoparticles and inclusion of the optimized formula with thermoresponsive triblock copolymers in in situ gel. Sixteen nanoparticle formulations were prepared by liquid-liquid phase separation method according to the D-optimal fractional factorial design encompassing five variables at two levels. The responses investigated were glimepiride entrapment capacity (EC), particle size and size distribution, zeta potential, and in vitro drug release from the prepared nanoparticles. Furthermore, the feasibility of embedding the optimized Zein-based glimepiride nanoparticles within thermoresponsive triblock copolymers poly(lactide-co-glycolide)-block-poly(ethylene glycol)-block-poly(lactide-co-glycolide) in in situ gel was evaluated for controlling glimepiride release rate. Through the systematic optimization phase, improvement of glimepiride EC of 33.6%, nanoparticle size of 120.9 nm with a skewness value of 0.2, zeta potential of 11.1 mV, and sustained release features of 3.3% and 17.3% drug released a...Continue Reading

Citations

Aug 24, 2017·Drug Development and Industrial Pharmacy·Tarek A AhmedFathy I Abd-Allah
Oct 1, 2020·Toxicology Reports·Jennifer Thayanne Cavalcante de AraújoFrancisco Fabio Oliveira de Sousa
Sep 17, 2017·International Journal of Biological Macromolecules·Hriday BeraSridhar Vanga
Jul 3, 2021·Polymers·Teresa BasinskaStanislaw Slomkowski
Aug 8, 2021·Advanced Drug Delivery Reviews·Xiaoyi Wang, Diane J Burgess

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Methods Mentioned

BETA
dynamic light scattering
interaction
profiler

Software Mentioned

Scientist
Statistical Analysis System ( JMP discovery
JMP
MicroMath

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