Mechanistic and pharmacological assessment of murine IL-23 mediated psoriasiform dermatitis; implications for drug discovery

Journal of Dermatological Science
Stephen B GauldSteven McGaraughty

Abstract

Animal models of Psoriasis (PsO) are important for our understanding of the pathophysiology of human disease but rarely manifest all features of the disease. In order to facilitate greater understanding of the underlying biology of PsO it is key that we understand the strengths and limitations of models used. While humanized mouse models are available for PsO they remain technically challenging, expensive, require prolonged timelines and require a continued source of human tissue. Another approach is to focus on developing mechanistic models which recapitulate key features of human PsO. The role of the IL-23/IL-17 pathway as a key driver of human PsO is both well characterized and clinically validated. The goal of this manuscript is to provide a comprehensive disease and pharmacological assessment of IL-23 driven skin inflammation and its similarity to human psoriatic skin. Intradermal injection of IL-23 has been used to study the IL-23 pathway in rodents, and this current study further characterizes pathology, cellular infiltrate, and gene signature kinetics, as well as the modulation of disease features by clinically relevant agents. Our results indicate that IL-23 triggers an early and robust activation of the immune system ...Continue Reading

Citations

Nov 16, 2019·The Journal of Experimental Medicine·Immo PrinzUlrich Mrowietz
Nov 30, 2019·Scientific Reports·Arun K KannanStephen B Gauld
Aug 4, 2019·The Journal of Pharmacology and Experimental Therapeutics·Stephen GauldPhilippe Masson
Jun 27, 2019·Scientific Reports·Viktor TodorovićVictoria E Scott
Feb 7, 2021·The Journal of Investigative Dermatology·Alex LipovskyEric R Goedken
Aug 31, 2021·MAbs·Li ZhouGeertruida Veldman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here