Mechanistic considerations on the wavelength-dependent variations of UVR genotoxicity and mutagenesis in skin: the discrimination of UVA-signature from UV-signature mutation

Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology
Hironobu Ikehata

Abstract

Ultraviolet radiation (UVR) predominantly induces UV-signature mutations, C → T and CC → TT base substitutions at dipyrimidine sites, in the cellular and skin genome. I observed in our in vivo mutation studies of mouse skin that these UVR-specific mutations show a wavelength-dependent variation in their sequence-context preference. The C → T mutation occurs most frequently in the 5'-TCG-3' sequence regardless of the UVR wavelength, but is recovered more preferentially there as the wavelength increases, resulting in prominent occurrences exclusively in the TCG sequence in the UVA wavelength range, which I will designate as a "UVA signature" in this review. The preference of the UVB-induced C → T mutation for the sequence contexts shows a mixed pattern of UVC- and UVA-induced mutations, and a similar pattern is also observed for natural sunlight, in which UVB is the most genotoxic component. In addition, the CC → TT mutation hardly occurs at UVA1 wavelengths, although it is detected rarely but constantly in the UVC and UVB ranges. This wavelength-dependent variation in the sequence-context preference of the UVR-specific mutations could be explained by two different photochemical mechanisms of cyclobutane pyrimidine dimer (CPD) fo...Continue Reading

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Citations

Aug 29, 2019·Photochemistry and Photobiology·Hironobu IkehataMasayuki Yamamoto
Nov 7, 2019·International Journal of Molecular Sciences·Ernesto RossiGiampaolo Tortora
Jul 30, 2020·International Journal of Molecular Sciences·Marta GerasymchukIgor Kovalchuk
Dec 20, 2019·Nucleic Acids Research·Natália Cestari MorenoCarlos Frederico Martins Menck
May 13, 2021·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Yuko IbukiTatsushi Toyooka
May 22, 2021·Frontiers in Genetics·John P BrabsonLuisa Cimmino

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