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Mechanistic deductions from multiple kinetic and solvent deuterium isotope effects and pH studies of pyridoxal phosphate dependent carbon-carbon lyases: Escherichia coli tryptophan indole-lyase

Biochemistry

Sep 20, 1988

D M Kiick, Robert Stephen Phillips

PMID: 3061452

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Abstract

Analysis of the pH dependence of the kinetic parameters and competitive inhibitor Ki values for tryptophan indole-lyase suggests two enzymic groups must be unprotonated in order to facilitate binding and catalysis of tryptophan. The V/K for tryptophan and the pKi for oxindolyl-L-alanine...read more

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Cysteine
Tryptophan
Vitamin B6 Measurement
Analog
Tautomer
Abufne
Catalysis
Cysteine Hydrochloride
Indoles
Tryptophanase
Paper Details
References
  • References11
  • Citations25
12
  • References11
  • Citations25
123

Mechanistic deductions from multiple kinetic and solvent deuterium isotope effects and pH studies of pyridoxal phosphate dependent carbon-carbon lyases: Escherichia coli tryptophan indole-lyase

Biochemistry

Sep 20, 1988

D M Kiick, Robert Stephen Phillips

PMID: 3061452

DOI:

Abstract

Analysis of the pH dependence of the kinetic parameters and competitive inhibitor Ki values for tryptophan indole-lyase suggests two enzymic groups must be unprotonated in order to facilitate binding and catalysis of tryptophan. The V/K for tryptophan and the pKi for oxindolyl-L-alanine...read more

Mentioned in this Paper

Cysteine
Tryptophan
Vitamin B6 Measurement
Analog
Tautomer

Related Papers

Paper Details
References
  • References11
  • Citations25
12
  • References11
  • Citations25
123

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