Mechanistic effects of long-term ultraviolet B irradiation induce epidermal and dermal changes in human skin xenografts.

The American Journal of Pathology
Akira HachiyaRaymond E Boissy

Abstract

UVB irradiation has been reported to induce photoaging and suppress systemic immune function that could lead to photocarcinogenesis. However, because of the paucity of an UVB-induced photodamaged skin model, precise and temporal mechanism(s) underlying the deleterious effects of long-term UVB exposure on human skin have yet to be delineated. In this study, we established a model using human skin xenografted onto severe combined immunodeficient mice, which were subsequently challenged by repeated UVB irradiation for 6 weeks. Three-dimensional optical image analysis of skin replicas and noninvasive biophysical measurements illustrated a significant increase in skin surface roughness, similar to premature photoaging, and a significant loss of skin elasticity after long-term UVB exposure. Resembling authentically aged skin, UVB-exposed samples exhibited significant increases in epithelial keratins (K6, K16, K17), elastins, and matrix metalloproteinases (MMP-1, MMP-9, MMP-12) as well as degradation of collagens (I, IV, VII). The UVB-induced deterioration of fibrous keratin intermediate filaments was also observed in the stratum corneum. Additionally, similarities in gene expression patterns between our model and chronologically aged...Continue Reading

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Citations

May 9, 2012·Archives of Dermatological Research·Konrad Kleszczyński, Tobias W Fischer
Jun 19, 2010·The American Journal of Pathology·Marta GarcíaFernando Larcher
Dec 3, 2014·Clinics in Plastic Surgery·Dallas R Buchanan, Allan E Wulc
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Mar 4, 2011·Experimental Dermatology·Minyoung JungEung Ho Choi
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May 15, 2020·International Journal of Molecular Sciences·Kyung-Eun LeeHyeonju Yeo
Feb 25, 2020·Journal of the Mechanical Behavior of Biomedical Materials·Y ZhaoD M Pierce
Sep 3, 2021·Developmental Cell·Meng-Yen LiElena Ezhkova

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