Mechanistic insight into the singlet oxygen-triggered expansion of hypoxia-responsive polymeric micelles

Biomaterials Science
Lina WangYanjun Zhao

Abstract

Nitroimidazole-bearing nanomedicine has been popular as a hypoxia-responsive platform for on-demand drug delivery. We report the singlet oxygen-responsive property of nitroimidazole-containing micelles and the corresponding reaction mechanism, which would pave the way for developing a dual hypoxia- and singlet oxygen-sensitive drug delivery nanoplatform based on a simple nitroimidazole moiety.

References

Oct 15, 1982·Biochemical Pharmacology·E D ClarkeP Wardman
Oct 5, 2001·American Journal of Clinical Oncology·S M EvansC J Koch
May 24, 2003·Biochemical and Biophysical Research Communications·Michael J Davies
Jan 27, 2004·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Michael J Davies
Nov 17, 2006·Pharmaceutical Research·V P Torchilin
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Sep 7, 2012·Neoplasia : an International Journal for Oncology Research·Lu JiangKristine Glunde
Dec 3, 2013·Biomaterials·Thavasyappan ThambiJae Hyung Park
Feb 21, 2014·Angewandte Chemie·F PercheV P Torchilin
Jul 7, 2015·Chemical Reviews·Timothy J Deming
Mar 2, 2016·Annals of Biomedical Engineering·Jicheng YuZhen Gu
Mar 8, 2016·Advanced Materials·Chenggen QianZhen Gu
Jun 16, 2016·Biomacromolecules·Prajakta KulkarniSanku Mallik
Feb 1, 2017·Angewandte Chemie·Chenggen QianZhen Gu
Feb 23, 2017·International Journal of Nanomedicine·Hong-Mei LiuRu-Tong Yu
May 22, 2017·Journal of Controlled Release : Official Journal of the Controlled Release Society·Xiaodan LiYanjun Zhao
Jul 7, 2017·Biomaterials Science·Juanjuan DangLichen Yin

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Citations

Sep 8, 2020·Advanced Healthcare Materials·Dandan LiJun Wu
Dec 29, 2018·Journal of Controlled Release : Official Journal of the Controlled Release Society·Camila G DarivaArménio C Serra
Aug 6, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yihenew Simegniew Birhan, Hsieh-Chih Tsai
Jun 15, 2019·ACS Applied Materials & Interfaces·Qi YanYanjun Zhao

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Methods Mentioned

BETA
NMR
amidation
fluorescence assay
Fluorescence

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