Mechanistic insights into the interactions of magnetic nanoparticles with bovine serum albumin in presence of surfactants

Colloids and Surfaces. B, Biointerfaces
Delina JosephSudeshna Chandra

Abstract

This work reports the physicochemical parameters and the nature of association between magnetic nanoparticles and bovine serum albumin (BSA) in presence of cationic and anionic surfactants. Magnetic iron oxide nanoparticles (MNPs) are first synthesized using chemical co-precipitation method and subsequently characterized by FTIR, XRD, DLS, TEM and Zeta potential. The bare nanoparticles are then coated with BSA and their interactions studied using fluorescence spectroscopy, dynamic light scattering and circular dichroism techniques. The spectroscopic investigation sheds light into various aspects of binding and size variation during the molecular association of BSA with the MNPs in absence and presence of cationic and anionic surfactants. Isothermal titration calorimetry was used to probe the thermodynamic parameters of the systems. MNPs-BSA system was found to be more stable in presence of cationic surfactant. This study provides valuable mechanistic insights into the interactions taking place at the interface of the nanoparticles which further helps in designing a stable colloidal MNPs systems.

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Citations

May 18, 2016·Nanomedicine : Nanotechnology, Biology, and Medicine·Lihui ZuHaishan Yang
Nov 1, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Arpan BhattacharyaTushar Kanti Mukherjee
Apr 19, 2019·Colloids and Surfaces. B, Biointerfaces·Brittany E GivensJennifer Fiegel
Nov 2, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Aparna SarafShilpee Sachar
Sep 21, 2021·Journal of Biomolecular Structure & Dynamics·Shruti G BhatkalkarShilpee Sachar

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