Mechanistic insights into the modulatory role of the mechanoreflex on central hemodynamics using passive leg movement in humans

Journal of Applied Physiology
Nicholas T KruseDarren P Casey

Abstract

The aim of this study was to examine the independent contributions of joint range of motion (ROM), muscle fascicle length (MFL), and joint angular velocity on mechanoreceptor-mediated central cardiovascular dynamics using passive leg movement (PLM) in humans. Twelve healthy men (age: 23 ± 2 yr, body mass index: 23.7 kg/m2) performed continuous PLM at various randomized joint angle ROMs (0°-50° vs. 50°-100° vs. 0°-100°) and joint angular velocities ("fast": 200°/s vs. "slow": 100°/s). Measures of heart rate (HR), cardiac output (CO), and mean arterial pressure (MAP) were recorded during baseline and during 60 s of PLM. MFL was calculated from muscle architectural measurements of fascicle pennation angle and tissue thickness (Doppler ultrasound). Percent change in MFL increased across the transition of PLM from 0° to 50° (15 ± 3%; P < 0.05) and from 0° to 100° knee flexion (27 ± 4%; P < 0.05). The average peak percent change in HR (increased, approx. +5 ± 2%; P < 0.05), CO (increased, approx. +5 ± 3%; P < 0.05), and MAP (decreased, approx. -2 ± 2%; P < 0.05) were similar between fast versus slow angular velocities when compared against shorter absolute joint ROMs (i.e., 0°-50° and 50°-100°). However, the condition that exhibited ...Continue Reading

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Citations

Jun 27, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Korynne S RollinsSteven W Copp
Nov 18, 2018·European Journal of Applied Physiology·Bahareh FouladiHeather Edgell
Jan 3, 2021·European Geriatric Medicine·Stany PerkisasAnne-Marie De Cock
Jan 14, 2022·European Journal of Applied Physiology·Nobuhiro NakamuraIsao Muraoka

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