Mechanistic insights revealed by lipid profiling in monogenic insulin resistance syndromes.

Genome Medicine
Michael EidenJulian L Griffin

Abstract

Evidence from several recent metabolomic studies suggests that increased concentrations of triacylglycerols with shorter (14-16 carbon atoms), saturated fatty acids are associated with insulin resistance and the risk of type 2 diabetes. Although causality cannot be inferred from association studies, patients in whom the primary cause of insulin resistance can be genetically defined offer unique opportunities to address this challenge. We compared metabolite profiles in patients with congenital lipodystrophy or loss-of-function insulin resistance (INSR gene) mutations with healthy controls. The absence of significant differences in triacylglycerol species in the INSR group suggest that changes previously observed in epidemiological studies are not purely a consequence of insulin resistance. The presence of triacylglycerols with lower carbon numbers and high saturation in patients with lipodystrophy suggests that these metabolite changes may be associated with primary adipose tissue dysfunction. The observed pattern of triacylglycerol species is indicative of increased de novo lipogenesis in the liver. To test this we investigated the distribution of these triacylglycerols in lipoprotein fractions using size exclusion chromatogra...Continue Reading

References

Jul 1, 1968·Comparative Biochemistry and Physiology·E K O'Hea, G A Leveille
May 3, 2005·The Journal of Clinical Investigation·Kerry L DonnellyElizabeth J Parks
Oct 13, 2007·The Plant Journal : for Cell and Molecular Biology·Max BylesjöJohan Trygg
Dec 2, 2008·BMC Bioinformatics·Ralf TautenhahnSteffen Neumann
Jan 24, 2009·The Journal of Clinical Investigation·Robert K SempleDavid B Savage
Mar 9, 2010·Metabolomics : Official Journal of the Metabolomic Society·Gregor McCombieJulian L Griffin
Mar 16, 2011·The Journal of Clinical Investigation·Eugene P RheeRobert E Gerszten
May 11, 2011·The Journal of Clinical Investigation·Alison SleighDavid B Savage
May 30, 2012·Journal of Proteomics·Alan M RaceJosephine Bunch
Sep 7, 2012·The American Journal of Clinical Nutrition·Ksenia SevastianovaHannele Yki-Järvinen
May 21, 2013·GigaScience·Reza M SalekChristoph Steinbeck
Nov 6, 2013·Molecular Nutrition & Food Research·Jane F FergusonMuredach P Reilly
Mar 6, 2015·Biological Reviews of the Cambridge Philosophical Society·Francis W B Sanders, Julian L Griffin

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Citations

Jan 31, 2016·Genome Medicine·Charles AuffrayMatthias Schwab
Apr 14, 2016·Biochemical Society Transactions·Francis SandersJulian L Griffin
Aug 23, 2019·Physiological Reviews·David S Wishart
Feb 14, 2017·Metabolomics : Official Journal of the Metabolomic Society·Animesh AcharjeeAlbert Koulman
Mar 13, 2021·The Journal of Clinical Endocrinology and Metabolism·Zhenhua NiuGeng Zong
Jun 8, 2017·Journal of Proteome Research·Elizabeth G StanleyJulian L Griffin
Dec 7, 2021·Critical Reviews in Food Science and Nutrition·Jing-Wen Yang, Hong-Fang Ji

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Datasets Mentioned

BETA
MTBLS162

Methods Mentioned

BETA
size exclusion chromatography

Software Mentioned

CAMERA
DA
O2PLS
R
DIMS
Excel
Prism
MetaboLights
MSconvert
InterAct

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