Mechanistic investigation into the arrhythmogenic role of transmural heterogeneities in regional ischaemia phase 1A.

Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology
Brock M TiceNatalia Trayanova

Abstract

Studies of arrhythmogenesis during ischemia have focused primarily on reentrant mechanisms manifested on the epicardial surface. The goal of this study was to use a physiologically-accurate model of acute regional ischemia phase 1A to determine the contribution of ischaemia-induced transmural electrophysiological heterogeneities to arrhythmogenesis following left anterior descending artery occlusion. A slice through a geometrical model of the rabbit ventricles was extracted and a model of regional ischaemia developed. The model included a central ischaemic zone incorporating transmural gradients of I(K(ATP)) activation and [K+]o, surrounded by ischaemic border zones (BZs), with the degree of ischaemic effects varied to represent progression of ischaemia 2-10 min post-occlusion. Premature stimulation was applied over a range of coupling intervals to induce re-entry. The presence of ischaemic BZs and a transmural gradient in I(K(ATP)) activation provided the substrate for re-entrant arrhythmias. Increased dispersion of refractoriness and conduction velocity in the BZs with time post-occlusion led to a progressive increase in arrhythmogenesis. In the absence of a transmural gradient of I(K(ATP)) activation, re-entry was rarely sus...Continue Reading

References

Dec 1, 1978·The American Journal of Cardiology·A H HarkenB Chance
Nov 1, 1977·The American Journal of Cardiology·J D HearseG Boulle
Aug 1, 1975·Circulation·M L MarcusF M Abboud
Nov 1, 1975·The American Journal of Cardiology·H BrooksL Resnekov
May 1, 1986·Pacing and Clinical Electrophysiology : PACE·D L JonesG J Klein
Sep 1, 1974·Circulation Research·R LazzaraB J Scherlag
Jun 1, 1981·The American Journal of Cardiology·D J Hearse, D M Yellon
Jan 1, 1980·Journal of Electrocardiology·C F BabbsL A Geddes
Mar 15, 1997·Journal of the American College of Cardiology·S BehrensM R Franz

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Citations

Feb 27, 2014·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Jose M FerreroLucia Romero
Jul 12, 2011·Heart Rhythm : the Official Journal of the Heart Rhythm Society·José M Di Diego, Charles Antzelevitch
Jul 16, 2010·Drug Discovery Today. Disease Models·Natalia A Trayanova, Brock M Tice
May 1, 2015·Biomedical Engineering Online·Alejandro Lopez-PerezJose M Ferrero
Nov 12, 2010·Expert Opinion on Drug Metabolism & Toxicology·Thomas MeyerUdo Kraushaar
Jun 24, 2016·Progress in Biophysics and Molecular Biology·Hermenegild J ArevaloNatalia A Trayanova
Jul 29, 2019·Journal of Mathematical Biology·Meena PargaeiLuca F Pavarino
Oct 23, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Le GuiQing-Hui Chen

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