Mechanistic Potential and Therapeutic Implications of Cannabinoids in Nonalcoholic Fatty Liver Disease

Medicines
Pratima DibbaAijaz Ahmed

Abstract

Nonalcoholic fatty liver disease (NAFLD) is comprised of nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH). It is defined by histologic or radiographic evidence of steatosis in the absence of alternative etiologies, including significant alcohol consumption, steatogenic medication use, or hereditary disorders. NAFLD is now the most common liver disease, and when NASH is present it can progress to fibrosis and hepatocellular carcinoma. Different mechanisms have been identified as contributors to the physiology of NAFLD; insulin resistance and related metabolic derangements have been the hallmark of physiology associated with NAFLD. The mainstay of treatment has classically involved lifestyle modifications focused on the reduction of insulin resistance. However, emerging evidence suggests that the endocannabinoid system and its associated cannabinoid receptors and ligands have mechanistic and therapeutic implications in metabolic derangements and specifically in NAFLD. Cannabinoid receptor 1 antagonism has demonstrated promising effects with increased resistance to hepatic steatosis, reversal of hepatic steatosis, and improvements in glycemic control, insulin resistance, and dyslipidemia. Literature regardin...Continue Reading

References

May 29, 1999·Gastroenterology·C A MatteoniA J McCullough
Apr 30, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Brent A Neuschwander-Tetri, Stephen H Caldwell
Nov 18, 2005·The New England Journal of Medicine·Jean-Pierre DesprésUNKNOWN Rimonabant in Obesity-Lipids Study Group
May 15, 2007·European Journal of Pharmacology·Francisco Javier Bermudez-SilvaFernando Rodríguez de Fonseca
May 26, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Magali Gary-BoboMohammed Bensaid
Oct 24, 2007·British Journal of Pharmacology·S LotersztajnA Mallat
Nov 3, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·A Mallat, S Lotersztajn
Dec 4, 2008·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Nila RafiqZobair M Younossi
Mar 17, 2009·Best Practice & Research. Clinical Endocrinology & Metabolism·Fabrício A MoreiraBeat Lutz
Mar 6, 2010·The AAPS Journal·Vishnudutt PurohitDavid Shurtleff
May 13, 2010·Digestive Diseases·Stefano BellentaniGiorgio Bedogni
Jun 30, 2010·International Journal of Clinical Practice·S KaserH Tilg
Jul 3, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Fatima Teixeira-ClercSophie Lotersztajn
Jul 7, 2010·Liver International : Official Journal of the International Association for the Study of the Liver·Andrea De GottardiAntoine Hadengue
Jul 29, 2010·The Journal of Clinical Investigation·Joseph TamGeorge Kunos
Oct 1, 2010·The New England Journal of Medicine·Giovanni TargherEnzo Bonora
Jan 22, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Joseph TamGeorge Kunos
Mar 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Bani MukhopadhyayGeorge Kunos
Jul 8, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Alexandre LouvetSophie Lotersztajn
Oct 9, 2012·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Donna L WhiteHashem B El-Serag
Apr 10, 2013·Journal of Hepatology·Ariane MallatSophie Lotersztajn
Jun 12, 2013·Journal of Hepatology·Fabio NascimbeniAmedeo Lonardo
Jan 1, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Robert J WongAijaz Ahmed
Apr 29, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Siddharth SinghRohit Loomba
Jan 18, 2015·Journal of Hepatology·Cristoforo SilvestriVincenzo Di Marzo
Jul 24, 2015·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Edith HochhauserZiv Ben Ari
Nov 26, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Fabio PiscagliaUNKNOWN HCC-NAFLD Italian Study Group
Apr 8, 2016·Obesity Facts·UNKNOWN European Association for the Study of the Liver (EASL)UNKNOWN European Association for the Study of Obesity (EASO)
Oct 22, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Zobair M YounossiRachel Beckerman
May 5, 2017·World Journal of Hepatology·George CholankerilSanjaya K Satapathy
Sep 21, 2017·Nature Reviews. Gastroenterology & Hepatology·Zobair YounossiElisabetta Bugianesi

❮ Previous
Next ❯

Citations

Feb 6, 2020·European Journal of Clinical Investigation·Somayyeh AsghariFarshad Amirkhizi
Aug 7, 2019·Bioscience of Microbiota, Food and Health·Chyntia Olivia Maurine JasirwanRino Alvani Gani
Jan 28, 2021·Journal of Clinical Medicine·Klaudia BerkAdrian Chabowski
Apr 8, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Jiabao LiaoHongwu Wang
Jul 25, 2021·International Journal of Molecular Sciences·Olivia WegrzyniakOlof Eriksson

❮ Previous
Next ❯

Methods Mentioned

BETA
surgical resection

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Related Papers

Nihon rinsho. Japanese journal of clinical medicine
Keisuke OeToshiji Saibara
Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte
Mariano MalaguarneraLucia Malaguarnera
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
Anna Sarosiekjeznach-SteinhagenIwona Boniecka
© 2022 Meta ULC. All rights reserved