PMID: 9422598Jan 9, 1998Paper

Mechanistic properties of the two-component bacteriocin lactococcin G

Journal of Bacteriology
G MollA J Driessen

Abstract

Lactococcin G is a bacteriocin whose activity depends on the complementary action of two peptides, termed alpha and beta. Biologically active, synthetic lactococcin G was used to study the mode of action on sensitive cells of Lactococcus lactis. The alpha and beta peptides can bind independently to the target cell surface, but activity requires the complementary peptide. Once bound to the cell surface, the peptides cannot be displaced to the surfaces of other cells. A complex of alpha and beta peptides forms a transmembrane pore that conducts monovalent cations but not protons. Efflux of potassium ions is observed only above pH 5.0, and the rate of efflux increases steeply with the pH. The consequences of cation fluxes for the viability of the target cells are discussed.

References

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Citations

Apr 28, 2000·Microbiology·B MartínezJ E Suárez
Aug 5, 2000·Applied and Environmental Microbiology·M C Martínez-CuestaG Buist
Aug 11, 2006·Biotechnology Letters·M Carmen Martínez-CuestaCarmen Peláez
Mar 6, 2007·Applied and Environmental Microbiology·Camilla OppegårdJon Nissen-Meyer
Apr 3, 2001·Applied and Environmental Microbiology·C HerranzM L Chikindas
Feb 22, 2001·Antimicrobial Agents and Chemotherapy·C HerranzA J Driessen
May 12, 2001·FEMS Microbiology Reviews·O McAuliffeC Hill
Sep 11, 2007·Journal of Molecular Microbiology and Biotechnology·Camilla OppegårdJon Nissen-Meyer
Apr 13, 2010·Probiotics and Antimicrobial Proteins·Jon Nissen-MeyerPer Eugen Kristiansen
May 5, 2006·Applied and Environmental Microbiology·Takeshi ZendoKenji Sonomoto
Aug 8, 2018·FEMS Microbiology Reviews·Jeella Z AcedoMarco J van Belkum
May 1, 2021·Animals : an Open Access Journal From MDPI·Juan Carlos Hernández-GonzálezNayeli Shantal Castrejón-Jiménez
Dec 22, 1999·Current Opinion in Chemical Biology·D G McCaffertyR Kruger
Nov 9, 2002·Biochimie·Sylvie GarneauJohn C Vederas
Jul 6, 2021·FEMS Microbiology Letters·François BourdichonLorenzo Morelli

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