Mechanistic similarity and diversity among the guanidine-modifying members of the pentein superfamily.

Biochimica Et Biophysica Acta
Thomas Linsky, Walter Fast

Abstract

The pentein superfamily is a mechanistically diverse superfamily encompassing both noncatalytic proteins and enzymes that catalyze hydrolase, dihydrolase and amidinotransfer reactions on guanidine substrates. Despite generally low sequence identity, they possess a conserved structural fold and display common mechanistic themes in catalysis. The structurally characterized catalytic penteins possess a conserved core of residues that include a Cys, His and two polar, guanidine-binding residues. All known catalytic penteins use the core Cys to attack the substrate's guanidine moiety to form a covalent thiouronium adduct and all cleave one or more of the guanidine C--N bonds. The mechanistic information compiled to date supports the hypothesis that this superfamily may have evolved divergently from a catalytically promiscuous ancestor.

References

Nov 1, 1985·Journal of Bacteriology·C Vander Wauven, V Stalon
Aug 8, 1998·Journal of Bacteriology·B L SchneiderL J Reitzer
Apr 1, 1999·Chemistry & Biology·P J O'Brien, D Herschlag
Dec 2, 2000·Nature Structural Biology·C M GroftS K Burley
Jun 19, 2001·Current Opinion in Structural Biology·S A TeichmannC Chothia
Aug 29, 2001·Nature Structural Biology·M Paoli
Aug 1, 1956·Archives of Biochemistry and Biophysics·S RATNER, O ROCHOVANSKY
Jan 1, 2004·The Journal of Biological Chemistry·Andrey GalkinOsnat Herzberg
Apr 29, 2004·Journal of the American Chemical Society·Xuefeng LuDebra Dunaway-Mariano
Jul 13, 2004·Nature Structural & Molecular Biology·Kyouhei AritaMamoru Sato
Dec 8, 2004·Archives of Biochemistry and Biophysics·John A GerltIvan Rayment
Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·A JannD Haas
Aug 29, 2006·Current Opinion in Chemical Biology·Margaret E GlasnerPatricia C Babbitt
Aug 31, 2006·Current Opinion in Chemical Biology·Olga KhersonskyDan S Tawfik
Feb 3, 2007·Nature Medicine·James LeiperPatrick Vallance
May 15, 2007·Biochemistry·Bryan KnuckleyPaul R Thompson
Jan 22, 2008·Journal of the American Chemical Society·Ling LiLiwen Zhang
May 17, 2008·Chemistry & Biology·Thomas W LinskyWalter Fast
Dec 17, 2009·Chembiochem : a European Journal of Chemical Biology·Bryan KnuckleyPaul R Thompson
Dec 29, 2009·Bioorganic Chemistry·Justin E JonesPaul R Thompson
Apr 2, 2010·The Journal of Biological Chemistry·Marco GartmannRoland Beckmann

❮ Previous
Next ❯

Citations

Oct 14, 2010·Biochemistry·Justin E JonesPaul R Thompson
Jan 13, 2011·Journal of the American Chemical Society·Corey M JohnsonWalter Fast
Jun 3, 2011·Journal of the American Chemical Society·Corey M JohnsonWalter Fast
May 15, 2015·Chemical Reviews·Jakob FuhrmannPaul R Thompson
Apr 15, 2011·Current Opinion in Chemical Biology·Daniel E Almonacid, Patricia C Babbitt
Dec 22, 2015·ACS Chemical Biology·Jakob Fuhrmann, Paul R Thompson
Jan 27, 2015·Nature Chemical Biology·Huw D LewisDavid M Wilson
May 5, 2017·Chembiochem : a European Journal of Chemical Biology·Christopher L SchardonWalter Fast
Jun 13, 2019·Biological Chemistry·Jürgen LassakWolfram Volkwein
Apr 27, 2021·Frontiers in Plant Science·Claudius MarondedzeChris Gehring

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.