Mechanistic studies and biological activity of bioxalomycin alpha 2, a novel antibiotic produced by Streptomyces viridodiastaticus subsp. "litoralis" LL-31F508.

Antimicrobial Agents and Chemotherapy
M P SinghD A Steinberg

Abstract

The bioxalomycins, a novel complex of broad-spectrum antibiotics, were isolated from fermentations of Streptomyces viridodiastaticus subsp. "litoralis" LL-31F508. Bioxalomycin alpha 2, the major component of this complex, exhibited antibacterial activity. The MICs ranged from < or = 0.002 to 0.008 micrograms/ml for gram-positive organisms and from 0.50 to 4 micrograms/ml for gram-negative organisms. Bioxalomycin alpha 2 was found to be bactericidal and to inhibit bacterial DNA synthesis preferentially. Bioxalomycin alpha 2 protected mice from a lethal challenge with Staphylococcus aureus Smith. The 50% effective dose of bioxalomycin alpha 2 administered orally was 10 times greater than that when the drug was given subcutaneously or intravenously. These data suggest a stability or bioavailability problem when the compound is administered orally.

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Citations

Jan 26, 2016·Natural Product Reports·Maya A Farha, Eric D Brown
May 29, 2018·BioMed Research International·Loh Teng-Hern TanBey-Hing Goh
May 9, 2002·Chemical Reviews·Jack D Scott, Robert M Williams
Feb 19, 2002·Chemical Reviews·Scott R. Rajski, Robert M. Williams

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