PMID: 25735390Mar 5, 2015Paper

Mechanistic studies of cyclin-dependent kinase inhibitor 3 (CDKN3) in colorectal cancer

Asian Pacific Journal of Cancer Prevention : APJCP
Cheng Yang, Jun-Jun Sun

Abstract

Colorectal cancer is one of the most severe subtypes of cancer, and has the highest propensity to manifest as metastatic disease. Because of the lack of knowledge of events that correlate with tumor cell migration and invasion, few therapeutic options are available. The current study aimed to explore the mechanism of colorectal cancer in hope of identifying the ideal target for future treatment. We first discovered the pro-tumor effect of a controversial cell cycle regulator, cylin-dependent kinase inhibitor 3 (CDKN3), which is highly expressed in colorectal cancer, and the possible related signaling pathways, by bioinformatics tools. We found that CDKN3 had remarkable effects in suppressing colorectal cancer cell proliferation and migration, inducing cell cycle arrest and apoptosis in a colorectal cancer cell line, SW480 cells. Our study, for the first time, provided consistent evidence showing overexpression of cell cycle regulator CDKN3, in colorectal cancer. The in vitro studies in SW480 cells revealed a unique role of CDKN3 in regulating cellular behavior of colorectal cancer cells, and implied the possibility of targeting CDKN3 as a novel treatment for colorectal cancer.

References

Jun 1, 1990·Cell·E R Fearon, B Vogelstein
Mar 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·G J HannonD Beach
Jul 1, 1999·Genes & Development·C J Sherr, J M Roberts
May 18, 2001·Nature·G I Evan, K H Vousden
Jan 16, 2002·Current Opinion in Genetics & Development·Alan Ho, Steven F Dowdy
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
May 15, 2003·Biochemical and Biophysical Research Communications·Chau-Ting YehMei-Ling Chao
Apr 28, 2010·Gastroenterology·Maria S Pino, Daniel C Chung
Jun 30, 2010·The Oncologist·Vanessa DeschoolmeesterJan B Vermorken
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Dec 3, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Ousman TamgueYan-Ming Wei
Mar 19, 2014·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Sep 18, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Ayla Valinezhad Orang, Abolfazl Barzegari
Oct 24, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Zhao-Xu ZhengWan-Qing Chen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.