Abstract
Colorectal cancer is one of the most severe subtypes of cancer, and has the highest propensity to manifest as metastatic disease. Because of the lack of knowledge of events that correlate with tumor cell migration and invasion, few therapeutic options are available. The current study aimed to explore the mechanism of colorectal cancer in hope of identifying the ideal target for future treatment. We first discovered the pro-tumor effect of a controversial cell cycle regulator, cylin-dependent kinase inhibitor 3 (CDKN3), which is highly expressed in colorectal cancer, and the possible related signaling pathways, by bioinformatics tools. We found that CDKN3 had remarkable effects in suppressing colorectal cancer cell proliferation and migration, inducing cell cycle arrest and apoptosis in a colorectal cancer cell line, SW480 cells. Our study, for the first time, provided consistent evidence showing overexpression of cell cycle regulator CDKN3, in colorectal cancer. The in vitro studies in SW480 cells revealed a unique role of CDKN3 in regulating cellular behavior of colorectal cancer cells, and implied the possibility of targeting CDKN3 as a novel treatment for colorectal cancer.
References
Jun 1, 1990·Cell·E R Fearon, B Vogelstein
Oct 6, 1995·Science·R Y Poon, T Hunter
Mar 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·G J HannonD Beach
Jul 1, 1999·Genes & Development·C J Sherr, J M Roberts
Feb 12, 2000·Molecular and Cellular Biology·S W LeeS A Aaronson
May 18, 2001·Nature·G I Evan, K H Vousden
Jan 16, 2002·Current Opinion in Genetics & Development·Alan Ho, Steven F Dowdy
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
May 15, 2003·Biochemical and Biophysical Research Communications·Chau-Ting YehMei-Ling Chao
May 19, 2004·Journal of Neurochemistry·Mihai D NiculescuSteven H Zeisel
Apr 28, 2010·Gastroenterology·Maria S Pino, Daniel C Chung
Jun 30, 2010·The Oncologist·Vanessa DeschoolmeesterJan B Vermorken
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Dec 3, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Ousman TamgueYan-Ming Wei
Mar 19, 2014·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Sep 18, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Ayla Valinezhad Orang, Abolfazl Barzegari
Oct 24, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Zhao-Xu ZhengWan-Qing Chen
Citations
Sep 1, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Mohamed M HafezOthman A Al-Shabanah
Feb 10, 2016·PloS One·Zofia WotschofskyHellmuth-Alexander Meyer
Jul 30, 2020·The Journal of International Medical Research·Wei DaiMingyi Li
Feb 1, 2020·Journal of Translational Medicine·Chen Hao JiangJian Ming Hu
Aug 13, 2021·Molecular Nutrition & Food Research·Simone G van BredaUNKNOWN PHYTOME consortium
Jan 22, 2017·Oncology Research·Huimin WangZhenmin Lu