Mechano- and thermosensitivity of regenerating cutaneous afferent nerve fibers.

Experimental Brain Research
W JänigNatalia Gorodetskaya

Abstract

Crush lesion of a skin nerve is followed by sprouting of myelinated (A) and unmyelinated (C) afferent fibers into the distal nerve stump. Here, we investigate quantitatively both ongoing activity and activity evoked by mechanical or thermal stimulation of the nerve in 43 A- and 135 C-fibers after crush lesion of the sural nerve using neurophysiological recordings in anesthetized rats. The discharge patterns in the injured afferent nerve fibers and in intact (control) afferent nerve fibers were compared. (1) Almost all (98%) A-fibers were mechanosensitive, some of them exhibited additionally weak cold/heat sensitivity; 7% had ongoing activity. (2) Three patterns of physiologically evoked activity were present in the lesioned C-fibers: (a) C-fibers with type 1 cold sensitivity (low cold threshold, inhibition on heating, high level of ongoing and cold-evoked activity; 23%): almost all of them were mechanoinsensitive and 40% of them were additionally heat-sensitive; (b) C-fibers with type 2 cold sensitivity (high cold threshold, low level of ongoing and cold-evoked activity; 23%). All of them were excited by mechanical and/or heat stimuli; (c) cold-insensitive C-fibers (54%), which were heat- and/or mechanosensitive. (3) The propor...Continue Reading

References

Mar 1, 1977·Journal of Neurophysiology·D R Kenshalo, R Duclaux
Nov 1, 1989·Quarterly Journal of Experimental Physiology : an International Journal of the Physiological Society·S J Lisney
Sep 1, 1985·Journal of Neurophysiology·V K Shea, E R Perl
Dec 1, 1984·Pain·H Blumberg, W Jänig
Dec 1, 1993·The Journal of Hand Surgery : Journal of the British Society for Surgery of the Hand·P HoffmannJ D Lubahn
May 1, 1993·Journal of Neurophysiology·J W LeemJ M Chung
Dec 1, 1996·The Journal of Physiology·M CamperoJ L Ochoa
Aug 10, 1999·The Journal of Comparative Neurology·J DegnJ Jakobsen
Jun 8, 2000·The Journal of Comparative Neurology·T TandrupR E Coggeshall
Sep 18, 2001·The Journal of Physiology·M CamperoJ L Ochoa
Feb 12, 2002·Nature Neuroscience·Félix VianaCarlos Belmonte
Jun 22, 2002·Nature·Haoxing XuDavid E Clapham
Mar 14, 2003·Journal of Neurophysiology·Michele L NealenMichael J Caterina
Jul 2, 2003·Neuroscience·P D ThutM S Gold
Jan 1, 1952·Acta Physiologica Scandinavica·E DODT, Y ZOTTERMAN
Nov 19, 2003·The European Journal of Neuroscience·Natalia GorodetskayaWilfrid Jänig
Oct 9, 1951·Acta Physiologica Scandinavica·H HENSEL, Y ZOTTERMAN
Mar 30, 2004·Neuron·Michael BandellArdem Patapoutian
Jul 16, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·C Jeffery WoodburyBrian M Davis
Sep 14, 2004·Journal of Neurobiology·Makoto Tominaga, Michael J Caterina
Sep 14, 2004·Journal of Neurobiology·Gary R Lewin, Rabih Moshourab
Jun 18, 2005·The Journal of Physiology·Elvira de la PeñaFélix Viana
Aug 3, 2005·Pflügers Archiv : European journal of physiology·Gordon Reid
Aug 20, 2005·The Journal of Clinical Investigation·Koichi ObataKoichi Noguchi
Dec 20, 2005·Pain·Jing HuGary R Lewin
Jan 27, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Laiche DjouhriSally N Lawson
May 25, 2006·Clinical Medicine & Research·Jason M SansoneSteven H Yale
Feb 9, 1909·The Journal of Physiology·W Trotter, H M Davies

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Citations

Apr 7, 2010·Cellular and Molecular Neurobiology·Xiaoqin ZhangBuwei Yu
Apr 30, 2013·Journal of Integrative Neuroscience·Alexander V ZevekeSofia A Polevaya
Oct 30, 2012·American Journal of Respiratory Cell and Molecular Biology·Gregory D ScottDavid B Jacoby
May 6, 2011·Arthritis Research & Therapy·Hans-Georg SchaibleGabriel Natura
Oct 1, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sarah E TaguePeter G Smith
Feb 11, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·M Camila AlmeidaAndrej A Romanovsky
Jun 4, 2013·The Journal of Pain : Official Journal of the American Pain Society·Anuradha ChakrabartyPeter G Smith
Jul 6, 2013·Dermatologic Clinics·Michael C Chen, Matthew H Meckfessel
Nov 6, 2010·The European Journal of Neuroscience·Alina TelibanWilfrid Jänig
Mar 4, 2015·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Alon LaiJames C Iatridis
Mar 29, 2011·Neuroscience Letters·Anuradha ChakrabartyPeter G Smith
Dec 31, 2014·Expert Opinion on Therapeutic Targets·Baojin HuaYanju Bao
Jan 20, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Zhi-Ling GuoJohn C Longhurst
Oct 16, 2010·Nature Medicine·Michael S Gold, Gerald F Gebhart
Sep 11, 2009·Journal of Neurophysiology·Natalia GorodetskayaWilfrid Jänig
Sep 25, 2016·Reviews in the Neurosciences·You-Quan DingJian-Guo Qi
Feb 11, 2011·Journal of Neurophysiology·Irina KirillovaWilfrid Jänig
Feb 28, 2014·Journal of Neurophysiology·Alina TelibanWilfrid Jänig
Jan 6, 2019·International Journal of Molecular Sciences·Marina Arribas-BlázquezAntonio R Artalejo
Feb 22, 2018·Journal of Neurophysiology·Jan TodeWilfrid Jänig

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