Mechano-adaptation of the stem cell nucleus

Nucleus
Su-Jin HeoRobert L Mauck

Abstract

Exogenous mechanical forces are transmitted through the cell and to the nucleus, initiating mechanotransductive signaling cascades with profound effects on cellular function and stem cell fate. A growing body of evidence has shown that the force sensing and force-responsive elements of the nucleus adapt to these mechanotransductive events, tuning their response to future mechanical input. The mechanisms underlying this "mechano-adaptation" are only just beginning to be elucidated, and it remains poorly understood how these components act and adapt in tandem to drive stem cell differentiation. Here, we review the evidence on how the stem cell nucleus responds and adapts to physical forces, and provide a perspective on how this mechano-adaptation may function to drive and enforce stem cell differentiation.

References

Feb 4, 1997·Proceedings of the National Academy of Sciences of the United States of America·A J ManiotisD E Ingber
Jul 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·R ZhengR Craigie
Jan 18, 2005·Journal of Cell Science·Ewa MarkiewiczChristopher J Hutchison
Feb 3, 2005·Nature Reviews. Molecular Cell Biology·Yosef GruenbaumKatherine L Wilson
Sep 24, 2005·Stem Cells·Dan ConstantinescuAntonei B Csoka
Feb 27, 2007·Cell·Aaron D GoldbergEmily Bernstein
Jun 7, 2007·Nature Reviews. Molecular Cell Biology·Harald HerrmannUeli Aebi
Aug 29, 2007·The Journal of Cell Biology·Qian LiuKyle J Roux
Sep 26, 2007·Proceedings of the National Academy of Sciences of the United States of America·J David PajerowskiDennis E Discher
Jun 7, 2008·Circulation Research·Kris Noel DahlJan Lammerding
Oct 24, 2008·Journal of Biomechanics·Julia T Philip, Kris Noel Dahl
Jan 31, 2009·Science·Armando del RioMichael P Sheetz
Feb 7, 2009·Nature Reviews. Molecular Cell Biology·Ning WangDonald E Ingber
May 11, 2010·Nature Cell Biology·Shigenobu YonemuraMai Shibata
May 29, 2010·Annual Review of Cell and Developmental Biology·Daniel A Starr, Heidi N Fridolfsson
Aug 24, 2010·Journal of Biomechanics·Emily J ArnsdorfChristopher R Jacobs
Nov 26, 2010·Nature·Pakorn KanchanawongClare M Waterman
Dec 22, 2010·Proceedings of the National Academy of Sciences of the United States of America·Eric S FolkerGregg G Gundersen
Feb 16, 2011·Cell Research·Andrew J Bannister, Tony Kouzarides
Apr 6, 2011·Biochemical and Biophysical Research Communications·John D FinanFarshid Guilak
Dec 29, 2011·Proceedings of the National Academy of Sciences of the United States of America·Janet M TseLance L Munn
Feb 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Ding-Yu LeeJeng-Jiann Chiu
Feb 22, 2012·Journal of Cell Science·Joana Borrego-PintoEdgar R Gomes
May 30, 2012·Nature Reviews. Genetics·Peter A Jones
Oct 16, 2012·Biophysical Journal·K Venkatesan IyerG V Shivashankar
Dec 6, 2012·Biology Open·Bingfeng ZuoLin Liu
Oct 22, 2013·Nature Materials·Timothy L DowningSong Li
Jan 1, 2014·Seminars in Cell & Developmental Biology·Kevin GessonRoland Foisner
Feb 25, 2014·Advances in Experimental Medicine and Biology·Celine Denais, Jan Lammerding
Mar 13, 2014·Nature Cell Biology·Christophe GuilluyKeith Burridge
Mar 19, 2014·Nature Materials·Chun YangKristi S Anseth
Apr 18, 2014·Journal of Cell Science·Vitaly KochinJohn E Eriksson
Jun 2, 2014·Nature Cell Biology·Stefan KutscheidtGregg G Gundersen
Aug 1, 2014·Nature Communications·Mingxi YaoJie Yan
Aug 16, 2014·Current Biology : CB·Amnon BuxboimDennis E Discher
Mar 12, 2015·Nature Reviews. Molecular Cell Biology·Ana Pombo, Niall Dillon
Jun 16, 2015·Nature Communications·Sarah M SchreinerMegan C King
Jun 18, 2015·Biophysical Journal·Tristan P DriscollRobert L Mauck

❮ Previous
Next ❯

Citations

Apr 27, 2018·Current Opinion in Clinical Nutrition and Metabolic Care·James G Ryall, Gordon S Lynch
Dec 28, 2018·Current Stem Cell Research & Therapy·Mehrdad M MoghaddamShahab Faghihi
Apr 15, 2020·Advanced Healthcare Materials·Eric N DaiRobert L Mauck
Apr 4, 2021·International Journal of Molecular Sciences·Ália Dos Santos, Christopher P Toseland

❮ Previous
Next ❯

Methods Mentioned

BETA
acetylation

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.