Dec 4, 2019

Mechano-electric and mechano-chemo-transduction in cardiomyocytes

The Journal of Physiology
Leighton T IzuLeighton Izu


Cardiac excitation-contraction (E-C) coupling is influenced by (at least) three dynamic systems that couple and feedback to one another (see Abstract Figure). Here we review the mechanical effects on cardiomyocytes that include mechano-electro-transduction (commonly referred to as mechano-electric coupling, MEC) and mechano-chemo-transduction (MCT) mechanisms at cell and molecular levels which couple to Ca2+ -electro and E-C coupling reviewed elsewhere. These feedback loops from muscle contraction and mechano-transduction to the Ca2+ homeodynamics and to the electrical excitation are essential for understanding the E-C coupling dynamic system and arrhythmogenesis in mechanically loaded hearts. This white paper comprises two parts, each reflecting key aspects from the 2018 UC Davis symposium: MEC (how mechanical load influences electrical dynamics) and MCT (how mechanical load alters cell signalling and Ca2+ dynamics). Of course, such separation is artificial since Ca2+ dynamics profoundly affect ion channels and electrogenic transporters and vice versa. In time, these dynamic systems and their interactions must become fully integrated, and that should be a goal for a comprehensive understanding of how mechanical load influences...Continue Reading

  • References78
  • Citations1


  • References78
  • Citations1


Mentioned in this Paper

Myocardial Contraction
G-Protein-Coupled Receptors
Excitation Contraction Coupling
Calcium ion
Mucoepidermoid Carcinoma
Anatomical Space Structure
Ion Channel
Administration of Antineoplastic Agent
Intercellular Communication Process
Excite cement

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