Mechano-Sensitive Synthetic Ion Channels

Journal of the American Chemical Society
Takahiro MuraokaKazushi Kinbara

Abstract

Mechanical stress is a ubiquitous stimulus sensed by membrane proteins, but rarely by synthetic molecules. Inspired by mechano-sensitive ion channels found in cell membranes, tension-responsive transmembrane multiblock amphiphiles were developed. In membranes, a single-transmembrane amphiphile responds to both expanding and contracting tensions to weaken and strengthen the stacking of membrane-spanning units, respectively, and ion transportation is triggered by expanding tension to form a supramolecular channel, while little transportation is observed under a tensionless condition. In contrast, a three-transmembrane amphiphile showed little spectroscopic response to tensions, likely due to weaker stacking of membrane-spanning units than in the single-transmembrane amphiphile. Nevertheless, the three-transmembrane amphiphile shows ion transportation by forming a unimolecular channel even under a tensionless condition, and the ion-transporting activity decreased with expanding tension. Interestingly, the estimated operating force of these synthetic systems was comparable to that of the mechano-sensitive proteins. This study opens the door toward new mechano-sensitive molecular devices.

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Citations

Jul 18, 2018·Faraday Discussions·Kazushi KinbaraMasahiro Takagi
Oct 23, 2019·Chemistry : a European Journal·Karolina StrakovaStefan Matile
Jan 11, 2020·ChemistryOpen·Xiang ZhangStefan Matile
Sep 21, 2019·Angewandte Chemie·Mariano MacchioneStefan Matile
Sep 14, 2019·Chembiochem : a European Journal of Chemical Biology·Steven VanuytselMark Ian Wallace
Sep 22, 2020·Chemical Science·Anna D PetersSimon J Webb
Apr 20, 2018·Journal of the Royal Society, Interface·Nobuo MisawaShoji Takeuchi
Jun 12, 2020·Nature Communications·Takahiro MuraokaKazushi Kinbara
Jun 4, 2020·Biomimetics·Zoran Jakšić, Olga Jakšić
Nov 29, 2020·Chemistry, an Asian Journal·Miki MoriKazushi Kinbara
Jan 14, 2021·Chemical Communications : Chem Comm·Qi XiaoJun-Li Hou
Feb 4, 2021·Angewandte Chemie·Francesca PiazzollaStefan Matile
Apr 29, 2021·Chemical Communications : Chem Comm·Yusuke ShimizuKazushi Kinbara
Jun 15, 2021·Acta Biomaterialia·Da ZouChun-Xia Zhao
Jul 30, 2021·Journal of the American Chemical Society·Carmen DomeneSimone Furini
Feb 13, 2019·Journal of the American Chemical Society·Antoine GoujonStefan Matile
Aug 30, 2018·Journal of the American Chemical Society·Naomi Sakai, Stefan Matile
Dec 8, 2020·ACS Applied Materials & Interfaces·Joseph Pazzi, Anand Bala Subramaniam
Jan 9, 2019·Journal of the American Chemical Society·Lucia M LeeStefan Matile
Jan 15, 2021·Journal of the American Chemical Society·Ryo SasakiKazushi Kinbara
Sep 10, 2021·Accounts of Chemical Research·Kohei SatoKazushi Kinbara

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