Mechanochemical Activation of Zinc and Application to Negishi Cross-Coupling

Angewandte Chemie
Qun CaoDuncan L Browne

Abstract

A form independent activation of zinc, concomitant generation of organozinc species and engagement in a Negishi cross-coupling reaction via mechanochemical methods is reported. The reported method exhibits a broad substrate scope for both C(sp3 )-C(sp2 ) and C(sp2 )-C(sp2 ) couplings and is tolerant to many important functional groups. The method may offer broad reaching opportunities for the in situ generation organometallic compounds from base metals and their concomitant engagement in synthetic reactions via mechanochemical methods.

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Citations

Sep 19, 2018·Organic & Biomolecular Chemistry·Qun CaoDuncan L Browne
Oct 20, 2018·Angewandte Chemie·Joseph L HowardDuncan L Browne
Feb 15, 2019·Chemistry : a European Journal·Yadong PangHajime Ito
Apr 30, 2019·ChemSusChem·Qun CaoDuncan L Browne
Jul 23, 2019·Chemical Communications : Chem Comm·Nicolas PétryFrédéric Lamaty
Nov 28, 2019·ChemSusChem·William I NicholsonDuncan L Browne
Dec 2, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marta A Andrade, Luísa M D R S Martins
Oct 9, 2020·Angewandte Chemie·Shengjun NiLukasz T Pilarski
Apr 10, 2021·ChemSusChem·Karen J Ardila-Fierro, José G Hernández
May 5, 2021·Chemical Communications : Chem Comm·N M RajendranSwadhin K Mandal
Apr 2, 2021·Chemistry : a European Journal·Jamie A Leitch, Duncan L Browne
Jul 15, 2021·The Journal of Organic Chemistry·Jamie A LeitchDuncan L Browne
Aug 4, 2021·Organic Letters·Andrew C JonesDuncan L Browne
Sep 18, 2020·Organic Letters·Andrew C JonesDuncan L Browne
Jan 9, 2020·The Journal of Organic Chemistry·JieXiang YinDuncan L Browne
Aug 7, 2021·Angewandte Chemie·William I NicholsonDuncan L Browne
Aug 19, 2021·Angewandte Chemie·William I NicholsonDuncan L Browne

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