Mechanochemical Preparation of Active Pharmaceutical Ingredients Monitored by In Situ Raman Spectroscopy

ACS Omega
Irena SovićEvelina Colacino

Abstract

The mechanochemical preparation of silver sulfadiazine and dantrolene, two marketed active pharmaceutical ingredients, was investigated by in situ Raman spectroscopy. For the first time, the mechanochemical transformations involving highly fluorescent compounds could be studied in situ with a high-resolution Raman system combined with a unique suitable Raman probe. Moreover, the kinetic features of the mechanochemical process were examined by a mathematical model allowing to describe the chemical changes under mechanical stress. This approach is promising both to broaden the scope of Raman in situ investigations that would otherwise be impossible and for process optimization at any scale.

References

Feb 1, 1978·Journal of Pharmaceutical Sciences·A Bult, H B Klasen
May 1, 1994·The Journal of Burn Care & Rehabilitation·F W FullerF C Nance
Jun 13, 2006·Current Problems in Dermatology·Alan B G Lansdown
May 22, 2008·Journal of the American Chemical Society·Dominik CincićWilliam Jones
Nov 3, 2010·The Journal of Pharmacy and Pharmacology·Tomislav Friščić, William Jones
Mar 10, 2011·Chemical Society Reviews·Achim StolleBernd Ondruschka
Sep 6, 2011·Chemical Society Reviews·Stuart L JamesDaniel C Waddell
May 1, 2012·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Nives GalićSnežana Miljanić
Dec 19, 2012·Nature Chemistry·Tomislav FriščićRobert E Dinnebier
Dec 21, 2012·Angewandte Chemie·Svitlana Chernousova, Matthias Epple
Dec 22, 2012·Expert Opinion on Drug Delivery·Changquan Calvin Sun
Jan 25, 2013·Chemical Society Reviews·Laszlo Takacs
Feb 1, 2013·Chemical Society Reviews·Vladimir ŠepelákPaul Heitjans
May 11, 2013·Chemical Society Reviews·Guan-Wu Wang
Nov 5, 2013·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·N Ramesh BabuY Erdoğdu
Nov 22, 2013·Chemical Communications : Chem Comm·Davin TanTomislav Friščić
Nov 20, 2014·Faraday Discussions·Ivan HalaszRobert E Dinnebier
Jan 14, 2016·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Aamer SaeedMauricio F Erben
Jan 15, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Nicholas R Rightmire, Timothy P Hanusa
Jan 13, 2017·The Journal of Organic Chemistry·José G Hernández, Carsten Bolm
Feb 6, 2017·ACS Central Science·Jean-Louis Do, Tomislav Friščić
May 10, 2017·Advanced Drug Delivery Reviews·Dritan Hasa, William Jones
Aug 25, 2017·Chemistry : a European Journal·José G Hernández
Jul 15, 2018·Bioorganic & Medicinal Chemistry Letters·Sreekanth ThotaEliezer J Barreiro
Aug 29, 2019·ACS Omega·Evelina ColacinoFrancesco Delogu
Jun 24, 2020·Physical Chemistry Chemical Physics : PCCP·Maria CartaAndrea Porcheddu

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Citations

Apr 10, 2021·ChemSusChem·Karen J Ardila-Fierro, José G Hernández

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Methods Mentioned

BETA
X-ray
Nuclear Magnetic Resonance

Software Mentioned

MCR
ALS
GramsAI
Matlab

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