Mechanoelectrical and voltage-gated ion channels in mammalian vestibular hair cells

Audiology & Neuro-otology
Ruth Anne EatockM A Vollrath

Abstract

Mammalian vestibular afferents respond robustly to head movements at low frequencies and provide input to reflexes that control eye, head and body position. Vestibular organs have distinctive regions and hair cells: Type II cells receive bouton afferent endings and type I cells receive large calyx afferent endings. In the rodent utricle, type II cells are broadly tuned to frequencies between 10 and 30 Hz. Other recent data suggest that otolith organs function in this frequency range, which is higher than previously imagined. Some of the tuning derives from adaptation of the transducer current, which is best fitted with a double exponential decay with time constants of approximately 4 and 40 ms. Further tuning is provided by basolateral conductances, principally outwardly rectifying, voltage-gated K+ conductances. The kinetics of the K+ currents tend to vary with location in the sensory epithelium and therefore may contribute to regional variation in afferent physiology. Type I hair cells have a large, negatively activating K+ conductance, g(K,L), that confers a very low input resistance and therefore attenuates the receptor potential. This may reduce nonlinearity in the receptor potential, a possibly useful feature for the moto...Continue Reading

Citations

Dec 17, 2008·Pflügers Archiv : European journal of physiology·Thien An Duong DinhAndreas Lückhoff
Sep 1, 2006·Cell and Tissue Research·Tobias MoserAnna Lysakowski
Oct 20, 2004·Journal of the Association for Research in Otolaryngology : JARO·Weng Hoe WongRuth Anne Eatock
May 2, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Gustavo AlvarezHanlin L Wang
Sep 21, 2004·Current Opinion in Otolaryngology & Head and Neck Surgery·John S Oghalai
Dec 14, 2005·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·J DupontD R Spriggs
Aug 13, 2004·Journal of Neurophysiology·R D RabbittS M Highstein
Feb 3, 2016·Hearing Research·Frances L Meredith, Katherine J Rennie
Feb 13, 2007·Brain Research·Sonia M S Rocha-SanchezKirk W Beisel
Apr 8, 2004·Journal of Clinical Pharmacy and Therapeutics·M Ranson, S Wardell
Mar 24, 2016·Nature Reviews. Clinical Oncology·Hollie J JacksonRenier J Brentjens
Sep 24, 2005·Journal of Neurophysiology·Joseph C HoltJay M Goldberg
Sep 11, 2003·Current Opinion in Neurobiology·Robert Fettiplace, Anthony J Ricci

❮ Previous
Next ❯

Related Concepts

Related Feeds

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Related Papers

Annals of the New York Academy of Sciences
Jeffrey R HoltRuth Anne Eatock
Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Bradley E LosavioPeter Saggau
Pflügers Archiv : European journal of physiology
Thien An Duong DinhAndreas Lückhoff
© 2022 Meta ULC. All rights reserved