Mechanokinetics of rapid tension recovery in muscle: the Myosin working stroke is followed by a slower release of phosphate

Biophysical Journal
David A Smith, John Sleep

Abstract

Crystallographic and biochemical evidence suggests that the myosin working stroke that generates force in muscle is accompanied by the release of inorganic phosphate (Pi), but the order and relative speed of these transitions is not firmly established. To address this problem, the theory of A. F. Huxley and R. M. Simmons for the length-step response is averaged over elastic strains imposed by filament structure and extended to include a Pi-release transition. Models of this kind are applied to existing tension-recovery data from length steps at different phosphate concentrations, and from phosphate jumps upon release of caged phosphate. This body of data is simulated by the model in which the force-generating event is followed by Pi release. A version in which the Pi-release transition is slow provides a better fit than a version with rapid Pi release and a slow transition preceding force generation. If Pi is released before force generation, the predicted rate of slow recovery increases with the size of the step, which is not observed. Some implications for theories of muscle contraction are discussed.

References

Apr 29, 1992·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·M A Geeves
May 1, 1992·The American Journal of Physiology·N C Millar, E Homsher
Dec 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·B Brenner
Dec 1, 1990·The Journal of Physiology·V Lombardi, G Piazzesi
Jun 1, 1989·Journal of Muscle Research and Cell Motility·E Pate, R Cooke
Jan 1, 1986·Annual Review of Biophysics and Biophysical Chemistry·M G Hibberd, D R Trentham
Jan 1, 1986·CRC Critical Reviews in Biochemistry·R Cooke
Feb 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·R F SiemankowskiH D White
Nov 1, 1985·Biophysical Journal·R Cooke, E Pate
Dec 7, 1971·Biochemistry·R W Lymn, E W Taylor
Oct 22, 1971·Nature·A F Huxley, R M Simmons
Feb 1, 1980·Biophysical Journal·E EisenbergY Chen
Nov 7, 1995·Proceedings of the National Academy of Sciences of the United States of America·J S Davis, M E Rodgers
Jun 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·Y D Chen, B Brenner
Aug 1, 1995·Biophysical Journal·D A Smith, M A Geeves
Aug 1, 1996·Journal of Muscle Research and Cell Motility·A F Huxley, S Tideswell
Feb 1, 1997·Current Biology : CB·K C Holmes
Apr 16, 1998·Journal of Muscle Research and Cell Motility·D A Smith
Nov 25, 1998·Biophysical Journal·E B GetzS L Lehman
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·T A Duke
Jun 29, 2000·Annual Review of Biochemistry·M A Geeves, K C Holmes
Apr 12, 2001·Current Opinion in Structural Biology·A Houdusse, H L Sweeney
Sep 23, 2003·Nature Structural Biology·Paul B ConibearAndrás Málnási-Csizmadia
Sep 23, 2003·Nature Structural Biology·Thomas F ReuboldDietmar J Manstein

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Citations

May 29, 2008·Annals of Biomedical Engineering·D A Smith, S M Mijailovich
Jul 22, 2008·Annals of Biomedical Engineering·D A SmithS M Mijailovich
Jun 17, 2008·Proceedings of the National Academy of Sciences of the United States of America·Mingxuan SunChristopher M Yengo
Apr 15, 2009·Proceedings. Biological Sciences·R C WoledgeN A Curtin
Jan 14, 2005·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Walter Steffen, John Sleep
Jan 14, 2005·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Miklós Nyitrai, Michael A Geeves
Jan 14, 2005·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Y TakagiY E Goldman
Sep 22, 2005·Proceedings of the National Academy of Sciences of the United States of America·Theresia KraftBernhard Brenner
Jan 24, 2006·Proceedings of the National Academy of Sciences of the United States of America·John SleepDavid Smith
Jul 16, 2010·Biophysical Chemistry·Ping Xie
Apr 3, 2010·Sleep Medicine Reviews·Damien Léger, Virginie Bayon
Dec 9, 2009·Advances in Pediatrics·Ian M PaulLeann L Birch
Oct 20, 2009·Child and Adolescent Psychiatric Clinics of North America·G J ReidD S Lewin
Mar 4, 2006·Biophysical Journal·V B SiththanandanM A Ferenczi
Jun 10, 2011·Child: Care, Health and Development·W A HallF Warnock
May 12, 2015·BioMed Research International·Alf MånssonGeorgios Tsiavaliaris
Aug 27, 2013·Biophysical Journal·Gerald Offer, K W Ranatunga
Mar 13, 2012·Biophysical Journal·Ryan N Mello, David D Thomas
May 6, 2016·Chronobiology International·Mariangela CerasuoloGianluca Ficca
Oct 19, 2005·Advances in Protein Chemistry·Michael A Geeves, Kenneth C Holmes
Nov 10, 2015·Sleep Medicine Reviews·Stephanie L AllenPenny V Corkum
Nov 3, 2016·Biophysical Journal·Gerald Offer, K W Ranatunga
Nov 10, 2012·Behavioral Sleep Medicine·Mona El-SheikhBrian E Vaughn
Oct 1, 2011·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Dean W Beebe
Jan 20, 2010·Journal of Muscle Research and Cell Motility·S-J Park-HolohanN A Curtin
Oct 30, 2007·The Journal of Biological Chemistry·Eva ForgacsHoward D White
Jun 27, 2017·Reports on Progress in Physics·M Caruel, L Truskinovsky
Jan 24, 2008·The Journal of Biological Chemistry·Máté GyimesiAndrás Málnási-Csizmadia
Dec 31, 2020·International Journal of Molecular Sciences·Peter FranzGeorgios Tsiavaliaris

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