Mechanoresponsive Properties of the Periodontal Ligament

Journal of Dental Research
L HuangJ A Helms

Abstract

The periodontal ligament (PDL) functions as an enthesis, a connective tissue attachment that dissipates strains created by mechanical loading. Entheses are mechanoresponsive structures that rapidly adapt to changes in their mechanical loading; here we asked which features of the PDL are sensitive to such in vivo loading. We evaluated the PDL in 4 physiologically relevant mechanical environments, focusing on mitotic activity, cell density, collagen content, osteogenic protein expression, and organization of the tissue. In addition to examining PDLs that supported teeth under masticatory loading and eruptive forces, 2 additional mechanical conditions were created and analyzed: hypoloading and experimental tooth movement. Collectively, these data revealed that the adult PDL is a remarkably quiescent tissue and that only when it is subjected to increased loads--such as those associated with mastication, eruption, and orthodontic tooth movement-does the tissue increase its rate of cell proliferation and collagen production. These data have relevance in clinical scenarios where PDL acclimatization can be exploited to optimize tooth movement.

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Citations

May 10, 2017·Journal of Dental Research·X PeiJ A Helms
Nov 7, 2019·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Lizheng WuXiaojing Wang
Jan 8, 2019·Journal of Dental Research·X ZhangJ A Helms
Oct 11, 2019·Korean Journal of Orthodontics·Won-Young ParkJin-Hyoung Cho
Nov 7, 2018·Dose-response : a Publication of International Hormesis Society·Stefan Judex, Suphannee Pongkitwitoon
Mar 14, 2019·Scientific Reports·Xiangyou LuoJingtao Li
Apr 12, 2019·Journal of Dental Research·Q XuJ A Helms
Feb 9, 2018·Journal of Dental Research·X YuanJ A Helms
Nov 24, 2020·Computer Methods in Biomechanics and Biomedical Engineering·Tomohiro OtaniMasao Tanaka
Jan 6, 2021·Clinical and Experimental Dental Research·Constanze SteinerAngelines Gasser
Jan 17, 2021·Archives of Oral Biology·Keng-Fu LanXiaojun Ding
Nov 7, 2020·Biochemical Society Transactions·Pierfrancesco PagellaThimios A Mitsiadis

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